Polymorphisms of the Interleukin-6 Gene Promoter and Abdominal Aortic Aneurysm

Smallwood, L., Allcock, R., van Bockxmeer, F., Warrington, N., Palmer, L. J., Iacopetta, B. and Norman, P. E. (2008) Polymorphisms of the Interleukin-6 Gene Promoter and Abdominal Aortic Aneurysm. European Journal of Vascular and Endovascular Surgery, 35 1: 31-36. doi:10.1016/j.ejvs.2007.08.021


Author Smallwood, L.
Allcock, R.
van Bockxmeer, F.
Warrington, N.
Palmer, L. J.
Iacopetta, B.
Norman, P. E.
Title Polymorphisms of the Interleukin-6 Gene Promoter and Abdominal Aortic Aneurysm
Journal name European Journal of Vascular and Endovascular Surgery   Check publisher's open access policy
ISSN 1078-5884
1532-2165
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.ejvs.2007.08.021
Volume 35
Issue 1
Start page 31
End page 36
Total pages 6
Place of publication London, United Kingdom
Publisher Elsevier Ltd
Language eng
Subject 2705 Cardiology and Cardiovascular Medicine
2741 Radiology Nuclear Medicine and imaging
2746 Surgery
Abstract Background: Elevated levels of circulating interleukin-6 (IL-6) have been reported in patients with abdominal aortic aneurysms (AAAs). Although this implicates inflammation as a cause of AAAs, there is also evidence that the aneurysmal aorta may secrete IL-6 into the circulation as a result of aortic proteolysis. Genetic association studies are one means of trying to clarify the role of specific mediators in the causal pathway. The aim of the present study was to examine the association between variants of the IL-6 gene and AAAs. Methods: An association study involving 677 men with screen-detected AAAs and 656 age-matched controls was performed. Three variants in the IL-6 promoter region were analysed: IL-6-174G > C (rs1800795), IL-6-572G > C (rs1800796) and IL-6-597G > A (rs1800797). Univariate regression of SNP genotype on AAA as a binary outcome was initially performed under a range of genetic models (additive, dominant and recessive). This was followed by multivariate analyses, testing the same models but including risk factors known to be associated with AAAs. All analyses and haplotype estimation were performed under a generalized linear model framework. Results: IL-6-572G > C polymorphism (frequency 1.5% in cases) was identified as an independent risk factor for AAA with an odds ratio (OR) of 6.00 (95%CI: 1.22, 29.41) when applied to the recessive model. No association was seen in the additive or dominant models. In a multivariate analysis using the most common haplotype (h.111, frequency 48.7%) as a reference, h.211 (frequency 4.4%) was an independent risk factor for AAA (OR 1.56, 95%CI: 1.02, 2.39). Conclusion: The IL-6 572G > C polymorphism (and h.211 haplotype) is associated with AAA, however it is too rare to be an important cause of most AAAs. This does not support the concept that the elevated level of IL-6 reported in patients with AAAs is a primary cause of the aneurysmal process.
Keyword Abdominal aortic aneurysm
Interleukin-6
Polymorphism
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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Created: Wed, 11 Jun 2014, 02:34:33 EST by Kylie Hengst on behalf of UQ Diamantina Institute