Matrix Metalloproteinase-2 Gene Variants and Abdominal Aortic Aneurysm

Smallwood, L., Warrington, N., Allcock, R., van Bockxmeer, F., Palmer, L. J., Iacopetta, B., Golledge, J. and Norman, P. E. (2009) Matrix Metalloproteinase-2 Gene Variants and Abdominal Aortic Aneurysm. European Journal of Vascular and Endovascular Surgery, 38 2: 169-171. doi:10.1016/j.ejvs.2009.04.019

Author Smallwood, L.
Warrington, N.
Allcock, R.
van Bockxmeer, F.
Palmer, L. J.
Iacopetta, B.
Golledge, J.
Norman, P. E.
Title Matrix Metalloproteinase-2 Gene Variants and Abdominal Aortic Aneurysm
Journal name European Journal of Vascular and Endovascular Surgery   Check publisher's open access policy
ISSN 1078-5884
Publication date 2009-01-01
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.ejvs.2009.04.019
Volume 38
Issue 2
Start page 169
End page 171
Total pages 3
Place of publication London, United Kingdom
Publisher Elsevier Ltd
Language eng
Subject 2705 Cardiology and Cardiovascular Medicine
2746 Surgery
Abstract Objective: To investigate associations between two polymorphisms of the matrix metalloproteinase-2 gene (MMP2) and the incidence and progression of abdominal aortic aneurysm (AAA). Methods: Cases and controls were recruited from a trial of screening for AAAs. The association between two variants of MMP2 (-1360C > T, and +649C > T) in men with AAA (n = 678) and in controls (n = 659) was examined using multivariate analyses. The association with AAA expansion (n = 638) was also assessed. Results: In multivariate analyses with adjustments for multiple testing, no association between either SNP and AAA presence or expansion was detected. Conclusion: MMP2 -1360C > T and +649C > T variants are not risk factors for AAA.
Keyword Abdominal aortic aneurysm
Genetic association study
Matrix metalloproteinase 2
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 7 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 11 Jun 2014, 02:27:11 EST by Kylie Hengst on behalf of UQ Diamantina Institute