Variants near CCNL1/LEKR1 and in ADCY5 and fetal growth characteristics in different trimesters

Mook-Kanamori, Dennis O., Marsh, Julie A., Warrington, Nicole M., Taal, H. Rob, Newnham, John P., Beilin, Lawrie J., Lye, Stephen J., Palmer, Lyle J., Hofman, Albert, Steegers, Eric A. P., Pennell, Craig E. and Jaddoe, Vincent W. V. (2011) Variants near CCNL1/LEKR1 and in ADCY5 and fetal growth characteristics in different trimesters. Journal of Clinical Endocrinology and Metabolism, 96 5: E810-E815. doi:10.1210/jc.2010-2316

Author Mook-Kanamori, Dennis O.
Marsh, Julie A.
Warrington, Nicole M.
Taal, H. Rob
Newnham, John P.
Beilin, Lawrie J.
Lye, Stephen J.
Palmer, Lyle J.
Hofman, Albert
Steegers, Eric A. P.
Pennell, Craig E.
Jaddoe, Vincent W. V.
Title Variants near CCNL1/LEKR1 and in ADCY5 and fetal growth characteristics in different trimesters
Formatted title
Variants near CCNL1/LEKR1 and in ADCY5 and Fetal Growth Characteristics in Different Trimesters 
Journal name Journal of Clinical Endocrinology and Metabolism   Check publisher's open access policy
ISSN 0021-972X
Publication date 2011-01-01
Year available 2011
Sub-type Article (original research)
DOI 10.1210/jc.2010-2316
Open Access Status Not yet assessed
Volume 96
Issue 5
Start page E810
End page E815
Total pages 6
Place of publication Chevy Chase, MD United States
Publisher The Endocrine Society
Language eng
Subject 1303 Specialist Studies in Education
1308 Clinical Biochemistry
1310 Endocrinology
2704 Biochemistry, medical
2712 Endocrinology, Diabetes and Metabolism
Abstract Context: A recent genome-wide association study identified variants near CCNL1/LEKR1 (rs900400) and in ADCY5 (rs9883204) to be associated with birth weight. We examined the associations of these variants with fetal growth characteristics in different trimesters, with a main interest in the timing of the associations and the affected body proportions. Methods: We used data from two prospective cohort studies from fetal life onward in The Netherlands and Australia. Repeated fetal ultrasound examinations were performed to measure head circumference (HC), abdominal circumference (AC), femur length (FL), and estimated fetal weight (EFW). Analyses were based on a total group of 3909 subjects. Results: The C-allele of rs900400 was associated in second trimester with smaller fetal HC and FL, and in third trimester with smaller HC, AC, FL, and EFW. For each C-allele, the combined effect estimate for EFW in third trimester was - 18.6 g (95% confidence interval, -27.5, -9.7 g; P = 4.2 x 10-5). The C-allele of rs9883204 was not associated with fetal growth characteristics in second trimester but was associated with restriction of all growth characteristics, except HC, in third trimesterandat birth. For each C-allele, thecombinedeffect estimatewas-16.9g(95%confidence interval, -26.8, -7.0 g; P = 8.4 x 10-4) for EFW in third trimester. Both genetic variants were associated with lower birth and placenta weight. Conclusions: Our results suggest that a genetic variant of rs900400 leads to symmetric growth restriction from early pregnancy onward, whereas a genetic variant of rs9883204 leads to asymmetric growth restriction, characterized by a relatively larger HC, from third trimester. Copyright
Keyword Endocrinology & Metabolism
Endocrinology & Metabolism
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 90700303
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
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Created: Wed, 11 Jun 2014, 01:47:54 EST by Kylie Hengst on behalf of UQ Diamantina Institute