Hospitalisation with infection, asthma and allergy in kawasaki disease patients and their families: Genealogical analysis using linked population data

Webster,Rebecca J., Carter, Kim W., Warrington, Nicole M., Loh, Angeline M., Zaloumis, Sophie, Kuijpers, Taco W., Palmer, Lyle J. and Burgner, David P. (2011) Hospitalisation with infection, asthma and allergy in kawasaki disease patients and their families: Genealogical analysis using linked population data. PLoS One, 6 11: e28004.1-e28004.11. doi:10.1371/journal.pone.0028004


Author Webster,Rebecca J.
Carter, Kim W.
Warrington, Nicole M.
Loh, Angeline M.
Zaloumis, Sophie
Kuijpers, Taco W.
Palmer, Lyle J.
Burgner, David P.
Title Hospitalisation with infection, asthma and allergy in kawasaki disease patients and their families: Genealogical analysis using linked population data
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2011-11-28
Sub-type Article (original research)
DOI 10.1371/journal.pone.0028004
Open Access Status DOI
Volume 6
Issue 11
Start page e28004.1
End page e28004.11
Total pages 11
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Language eng
Subject 1100 Agricultural and Biological Sciences
1300 Biochemistry, Genetics and Molecular Biology
2700 Medicine
Abstract Background: Kawasaki disease results from an abnormal immunological response to one or more infectious triggers. We hypothesised that heritable differences in immune responses in Kawasaki disease-affected children and their families would result in different epidemiological patterns of other immune-related conditions. We investigated whether hospitalisation for infection and asthma/allergy were different in Kawasaki disease-affected children and their relatives. Methods/Major Findings: We used Western Australian population-linked health data from live births (1970-2006) to compare patterns of hospital admissions in Kawasaki disease cases, age- and sex-matched controls, and their relatives. There were 295 Kawasaki disease cases and 598 age- and sex-matched controls, with 1,636 and 3,780 relatives, respectively. Compared to controls, cases were more likely to have been admitted at least once with an infection (cases, 150 admissions (50.8%) vs controls, 210 admissions (35.1%); odds ratio (OR) = 1.9, 95% confidence interval (CI) 1.4-2.6, P = 7.2×10-6), and with asthma/allergy (cases, 49 admissions (16.6%) vs controls, 42 admissions (7.0%); OR = 2.6, 95% CI 1.7-4.2, P = 1.3×10-5). Cases also had more admissions per person with infection (cases, median 2 admissions, 95% CI 1-5, vs controls, median 1 admission, 95% CI 1-4, P = 1.09×10-5). The risk of admission with infection was higher in the first degree relatives of Kawasaki disease cases compared to those of controls, but the differences were not significant. Conclusion: Differences in the immune phenotype of children who develop Kawasaki disease may influence the severity of other immune-related conditions, with some similar patterns observed in relatives. These data suggest the influence of shared heritable factors in these families.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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Created: Wed, 11 Jun 2014, 01:25:45 EST by Kylie Hengst on behalf of UQ Diamantina Institute