Discovery, synthesis, and structure: activity relationships of conotoxins

Akondi, Kalyana, Muttenthaler, Markus, Dutertre, Sébastien, Kaas, Quentin, Craik, David J., Lewis, Richard J. and Alewood, Paul F. (2014) Discovery, synthesis, and structure: activity relationships of conotoxins. Chemical Reviews, Articles ASAP 11: 1-33. doi:10.1021/cr400401e

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Author Akondi, Kalyana
Muttenthaler, Markus
Dutertre, Sébastien
Kaas, Quentin
Craik, David J.
Lewis, Richard J.
Alewood, Paul F.
Title Discovery, synthesis, and structure: activity relationships of conotoxins
Journal name Chemical Reviews   Check publisher's open access policy
ISSN 0009-2665
1520-6890
Publication date 2014-04-10
Year available 2014
Sub-type Article (original research)
DOI 10.1021/cr400401e
Open Access Status
Volume Articles ASAP
Issue 11
Start page 1
End page 33
Total pages 33
Place of publication Washington, DC, United States
Publisher American Chemical Society
Language eng
Formatted abstract
Peptide therapeutics are acclaimed as a promising addition to the pharmaceutical arena, and they continue to attract interest due to their high potency, bioavailability, and fewer concerns with toxicity, drug to drug cross-reactions, and tissue accumulation. Although poor drug delivery and low in vivo stability are still issues to be addressed, peptides look poised to play an important role in the treatment of diseases ranging from Alzheimer’s disease to cancer. The huge biodiversity offered by venom peptides, especially conotoxins isolated from the venom of predatory marine snails, holds enormous promise for the development of peptide-based drugs.
Keyword Chemistry, Multidisciplinary
Chemistry
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID APP1019761
DP1093115
APP631457
254897
Institutional Status UQ
Additional Notes Publication Date (Web): April 10, 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 51 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 57 times in Scopus Article | Citations
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Created: Wed, 04 Jun 2014, 20:55:29 EST by Susan Allen on behalf of Institute for Molecular Bioscience