Preterm labour: association between labour physiology, tocolysis and prevention

Illanes, Sebastian E., Perez-Sepulveda, Alejandra, Rice, Gregory E. and Mitchell, Murray D. (2014) Preterm labour: association between labour physiology, tocolysis and prevention. Expert Opinion on Investigational Drugs, 23 6: 759-771. doi:10.1517/13543784.2014.905541


Author Illanes, Sebastian E.
Perez-Sepulveda, Alejandra
Rice, Gregory E.
Mitchell, Murray D.
Title Preterm labour: association between labour physiology, tocolysis and prevention
Journal name Expert Opinion on Investigational Drugs   Check publisher's open access policy
ISSN 1744-7658
1354-3784
Publication date 2014-06-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1517/13543784.2014.905541
Volume 23
Issue 6
Start page 759
End page 771
Total pages 13
Place of publication London, United Kingdom
Publisher Informa Healthcare
Language eng
Formatted abstract
Introduction: In developed countries, preterm birth is the major cause of perinatal morbidity, mortality and the most important public health problem in the obstetric field. In the past decades, an increasing trend has been observed regardless of the great efforts focussed on the improvement of our understanding of the physiopathological mechanisms behind preterm labour (PTL) and the improvement in the use of tocolytic drugs.

Areas covered: In this review, the authors focus on some points of the physiopathology of labour in order to understand the rationality behind the different management approaches developed for the PTL syndrome.

Expert opinion: There is a need to develop new tools for the treatment of patients with PTL. Research focussed on improving tocolysis, the physiology of labour and pathological processes involved in PTL would afford new approaches for the treatment of PTL, allowing clinicians to provide integrative solutions for this multifactorial disease. Recently, the prophylactic use of progesterone pessary and cerclage in women with high risk of premature labour has been reported to reduce the incidence of premature births and improve neonatal outcomes. These results highlight the importance of prediction models in order to establish preventative strategies early in pregnancy.





Keyword Calcium regulation
Labour physiology
Preterm labour
Preterm labour prevention
Tocolysis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2015 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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