Odor memories regulate olfactory receptor expression in the sensory periphery

Claudianos, Charles, Lim, Julianne, Young, Melanie, Yan, Shanzhi, Cristino, Alexandre S., Newcomb, Richard D., Gunasekaran, Nivetha and Reinhard, Judith (2014) Odor memories regulate olfactory receptor expression in the sensory periphery. European Journal of Neuroscience, 39 10: 1642-1654. doi:10.1111/ejn.12539

Author Claudianos, Charles
Lim, Julianne
Young, Melanie
Yan, Shanzhi
Cristino, Alexandre S.
Newcomb, Richard D.
Gunasekaran, Nivetha
Reinhard, Judith
Title Odor memories regulate olfactory receptor expression in the sensory periphery
Journal name European Journal of Neuroscience   Check publisher's open access policy
ISSN 1460-9568
Publication date 2014-05-01
Year available 2014
Sub-type Article (original research)
DOI 10.1111/ejn.12539
Volume 39
Issue 10
Start page 1642
End page 1654
Total pages 13
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell
Language eng
Subject 2800 Neuroscience
Formatted abstract
Odor learning induces structural and functional modifications throughout the olfactory system, but it is currently unknown whether this plasticity extends to the olfactory receptors (Or) in the sensory periphery. Here, we demonstrate that odor learning induces plasticity in olfactory receptor expression in the honeybee, Apis mellifera. Using quantitative RT-PCR analysis, we show that six putative floral scent receptors were differentially expressed in the bee antennae depending on the scent environment that the bees experienced. Or151, which we characterized using an in vitro cell expression system as a broadly tuned receptor binding floral odorants such as linalool, and Or11, the specific receptor for the queen pheromone 9-oxo-decenoic acid, were significantly down-regulated after honeybees were conditioned with the respective odorants in an olfactory learning paradigm. Electroantennogram recordings showed that the neural response of the antenna was similarly reduced after odor learning. Long-term odor memory was essential for inducing these changes, suggesting that the molecular mechanisms involved in olfactory memory also regulate olfactory receptor expression. Our study demonstrates for the first time that olfactory receptor expression is experience-dependent and modulated by scent conditioning, providing novel insight into how molecular regulation at the periphery contributes to plasticity in the olfactory system.
Keyword Honeybee
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 22 times in Scopus Article | Citations
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