Low serum 25-hydroxyvitamin D concentrations associate with non-alcoholic fatty liver disease in adolescents independent of adiposity

Black, Lucinda J., Jacoby, Peter, She Ping-Delfos, Wendy Chan, Mori, Trevor A, Beilin, Lawrence J., Olynyk, John K., Ayonrinde, Oyekoya T., Huang, Rae Chi, Holt, Patrick G., Hart, Prue H., Oddy, Wendy H. and Adams, Leon A. (2014) Low serum 25-hydroxyvitamin D concentrations associate with non-alcoholic fatty liver disease in adolescents independent of adiposity. Journal of Gastroenterology and Hepatology (Australia), 29 6: 1215-1222. doi:10.1111/jgh.12541


Author Black, Lucinda J.
Jacoby, Peter
She Ping-Delfos, Wendy Chan
Mori, Trevor A
Beilin, Lawrence J.
Olynyk, John K.
Ayonrinde, Oyekoya T.
Huang, Rae Chi
Holt, Patrick G.
Hart, Prue H.
Oddy, Wendy H.
Adams, Leon A.
Title Low serum 25-hydroxyvitamin D concentrations associate with non-alcoholic fatty liver disease in adolescents independent of adiposity
Journal name Journal of Gastroenterology and Hepatology (Australia)   Check publisher's open access policy
ISSN 1440-1746
0815-9319
Publication date 2014-06-01
Sub-type Article (original research)
DOI 10.1111/jgh.12541
Open Access Status
Volume 29
Issue 6
Start page 1215
End page 1222
Total pages 8
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Language eng
Formatted abstract
Background and Aims
Non-alcoholic fatty liver disease (NAFLD) and serum 25-hydroxyvitamin D (s25[OH]D) concentrations are both associated with adiposity and insulin resistance (IR) and thus may be pathogenically linked. We aimed to determine the prevalence of vitamin D deficiency in adolescents with NAFLD and to investigate the prospective and cross-sectional associations between s25[OH]D concentrations and NAFLD.

Methods
Participants in the population-based West Australian Pregnancy (Raine) Cohort had seasonally adjusted s25(OH)D concentrations determined at ages 14 and then 17 years. NAFLD was diagnosed at 17 years using liver ultrasonography. Associations were examined after adjusting for potential confounders. Odds ratios (ORs) and confidence intervals (CIs) are reported per standard deviation in s25(OH)D concentrations.

Results
NAFLD was present in 16% (156/994) of adolescents. The majority of participants with NAFLD had either insufficient (51%) or deficient (17%) vitamin D status. s25(OH)D concentrations at 17 years were inversely associated with risk of NAFLD (OR 0.74, 95% CI 0.56, 0.97; P = 0.029), after adjusting for sex, race, physical activity, television/computer viewing, body mass index, and IR. The effect of s25(OH)D concentrations at 17 years was minimally affected after further adjusting for s25(OH)D concentrations at 14 years (OR 0.76, 95% CI 0.56, 1.03; P = 0.072).

Conclusions
Lower s25(OH)D concentrations are significantly associated with NAFLD, independent of adiposity and IR. Screening for vitamin D deficiency in adolescents at risk of NAFLD is appropriate, and clinical trials investigating the effect of vitamin D supplementation in the prevention and treatment of NAFLD may be warranted.
Keyword 25-hydroxyvitamin D
Non-alcoholic fatty liver disease
Obesity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Queensland Children's Medical Research Institute Publications
 
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