Differential induction of connexins 26 and 30 in skin tumors and their adjacent epidermis

Haass N.K., Wladykowski E., Kief S., Moll I. and Brandner J.M. (2006) Differential induction of connexins 26 and 30 in skin tumors and their adjacent epidermis. Journal of Histochemistry and Cytochemistry, 54 2: 171-182. doi:10.1369/jhc.5A6719.2005

Author Haass N.K.
Wladykowski E.
Kief S.
Moll I.
Brandner J.M.
Title Differential induction of connexins 26 and 30 in skin tumors and their adjacent epidermis
Journal name Journal of Histochemistry and Cytochemistry   Check publisher's open access policy
ISSN 0022-1554
Publication date 2006-01-01
Year available 2006
Sub-type Article (original research)
DOI 10.1369/jhc.5A6719.2005
Volume 54
Issue 2
Start page 171
End page 182
Total pages 12
Language eng
Subject 1307 Cell Biology
2702 Anatomy
Abstract Gap junctions (GJs) have been shown to play a role in tumor progression including a variety of keratinocyte-derived and non-keratinocyte-derived skin tumors. Here we show that the synthesis of the GJ proteins connexin 26 and connexin 30 (Cx26 and Cx30) is induced in keratinocyte-derived epithelial skin tumors whereas there is either no change or a downregulation of Cx43, Cx26, CxBO, and Cx43 are absent in non-epithelial skin tumors. Further, Cx26 and Cx30 are induced in the epidermis adjacent to malignant melanoma but absent in the epidermis adjacent to benign non-epithelial skin lesions (melanocytic nevi and angioma). The keratinocyte-derived skin tumors are very heterogeneous regarding the Cx26/Cx30 pattern in the epidermis at the periphery of the tumors. We did not observe any difference in the localization of the very similar proteins Cx26 and Cx30 but a variation in intensity of immunoreactivity. As the staining patterns of Cx26 and Cx30 antibodies are not identical to those of CK6, a marker for hyperproliferation, and CK17, a marker for trauma, we discuss that the induction of these gap junctional proteins exceeds a reflection of reactive hyperproliferative or traumatized epidermis. We further discuss the putative roles of these gap junctional proteins in tumor progression.
Keyword Basal cell carcinoma
Cell-cell communication
Gap junction
Skin cancer
Squamous cell carcinoma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
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Citation counts: TR Web of Science Citation Count  Cited 28 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 29 times in Scopus Article | Citations
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Created: Sat, 31 May 2014, 04:19:22 EST by Nikolas Haass