Ki67 expression levels are a better marker of reduced melanoma growth following MEK inhibitor treatment than phospho-ERK levels

Smalley, K. S. M., Contractor, R., Haass, N. K., Lee, J. T., Nathanson, K. L., Medina, C. A., Flaherty, K. T. and Herlyn, M. (2007) Ki67 expression levels are a better marker of reduced melanoma growth following MEK inhibitor treatment than phospho-ERK levels. British Journal of Cancer, 96 3: 445-449. doi:10.1038/sj.bjc.6603596


Author Smalley, K. S. M.
Contractor, R.
Haass, N. K.
Lee, J. T.
Nathanson, K. L.
Medina, C. A.
Flaherty, K. T.
Herlyn, M.
Title Ki67 expression levels are a better marker of reduced melanoma growth following MEK inhibitor treatment than phospho-ERK levels
Journal name British Journal of Cancer   Check publisher's open access policy
ISSN 0007-0920
1532-1827
Publication date 2007-02-12
Sub-type Article (original research)
DOI 10.1038/sj.bjc.6603596
Open Access Status DOI
Volume 96
Issue 3
Start page 445
End page 449
Total pages 5
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract The loss of tumour phospho-extracellular responsive kinase (pERK) positivity is the major treatment biomarker for mitogen-activated protein kinase/extracellular responsive kinase (MEK) inhibitors. Here, we demonstrate that there is a poor correlation between pERK inhibition and the anti-proliferative effects of MEK inhibitors in melanoma cells. We suggest that Ki67 is a better biomarker for future clinical studies.
Keyword Akt
Biomarker
BRAF
Ki67
MAP kinase
Melanoma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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