In vitro three-dimensional tumor microenvironment models for anticancer drug discovery

Smalley, Keiran S. M., Lioni, Mercedes, Noma, Kazuhiro, Haass, Nikolas K. and Herlyn, Meenhard (2008) In vitro three-dimensional tumor microenvironment models for anticancer drug discovery. Expert Opinion on Drug Discovery, 3 1: 1-10. doi:10.1517/17460441.3.1.1


Author Smalley, Keiran S. M.
Lioni, Mercedes
Noma, Kazuhiro
Haass, Nikolas K.
Herlyn, Meenhard
Title In vitro three-dimensional tumor microenvironment models for anticancer drug discovery
Journal name Expert Opinion on Drug Discovery   Check publisher's open access policy
ISSN 1746-0441
1746-045X
Publication date 2008-01-01
Year available 2008
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1517/17460441.3.1.1
Volume 3
Issue 1
Start page 1
End page 10
Total pages 10
Place of publication London, United Kingdom
Publisher Informa Healthcare
Language eng
Subject 3002 Drug Discovery
Abstract Anticancer drug discovery has long been hampered by the poor predictivity of the preclinical models. There is a growing realization that the tumor microenvironment is a critical determinant of the response of cancer cells to therapeutic agents. The past 5 years have seen a great deal of progress in our understanding of how the three-dimensional microenvironment modulates the signaling behavior of tumor cells. The present review discusses how three-dimensional in vitro cell culture models can benefit cancer drug discovery through an accurate modeling of the tumor microenvironment, leading to more physiologically relevant experimental outcomes.
Keyword Angiogenesis
Breast
Cancer
Esophagusoncology
Organotypic
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: UQ Diamantina Institute Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 34 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 38 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sat, 31 May 2014, 04:05:31 EST by Nikolas Haass on behalf of UQ Diamantina Institute