The amyloid precursor protein copper binding domain histidine residues 149 and 151 mediate APP stability and metabolism

Spoerri, Loredana, Vella, Laura J., Pham, Chi L. L., Barnham, Kevin J. and Cappai, Roberto (2012) The amyloid precursor protein copper binding domain histidine residues 149 and 151 mediate APP stability and metabolism. Journal of Biological Chemistry, 287 32: 26840-26853. doi:10.1074/jbc.M112.355743


Author Spoerri, Loredana
Vella, Laura J.
Pham, Chi L. L.
Barnham, Kevin J.
Cappai, Roberto
Title The amyloid precursor protein copper binding domain histidine residues 149 and 151 mediate APP stability and metabolism
Journal name Journal of Biological Chemistry   Check publisher's open access policy
ISSN 0021-9258
1083-351X
Publication date 2012-08-03
Sub-type Article (original research)
DOI 10.1074/jbc.M112.355743
Open Access Status DOI
Volume 287
Issue 32
Start page 26840
End page 26853
Total pages 14
Place of publication Bethesda, MD, United States
Publisher American Society for Biochemistry and Molecular Biology
Language eng
Formatted abstract
Background: Copper modulates the metabolism of the Alzheimer disease amyloid precursor protein (APP).

Results: Histidine residues 149 and 151 of APP copper binding domain modulate APP ER-to-Golgi trafficking.

Conclusion: Histidines residues 149 and 151 of APP are pivotal for APP proteolytic processing.

Significance: Elucidating the copper binding domain elements involved in APP stabilization and metabolism is crucial for understanding the physiological role of APP.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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Created: Fri, 30 May 2014, 23:50:07 EST by Loredana Spoerri on behalf of UQ Diamantina Institute