Melanoma never says die

Haass, Nikolas K. and Schumacher, Udo (2014) Melanoma never says die. Experimental Dermatology, 23 7: 471-472. doi:10.1111/exd.12400

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Author Haass, Nikolas K.
Schumacher, Udo
Title Melanoma never says die
Formatted title
Melanoma never says die. Commentary on Plötz & Eberle: BH3-only proteins – possible proapoptotic triggers for melanoma therapy
Journal name Experimental Dermatology   Check publisher's open access policy
ISSN 0906-6705
1600-0625
Publication date 2014-07-16
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/exd.12400
Volume 23
Issue 7
Start page 471
End page 472
Total pages 2
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Drug resistance in melanoma is commonly attributed to ineffective apoptotic pathways. Targeting apoptosis regulators is thus considered a promising approach to sensitizing melanoma to therapy. In this issue of Experimental Dermatology, Plötz & Eberle discuss the role that apoptosis plays in melanoma progression and drug resistance and the utility of apoptosis-inducing BH3-mimetics as targeted therapy. There are a number of compounds in clinical development and the field seems close to translating recent findings into benefits for melanoma patients. Thus this viewpoint is timely and achieves a valuable summary of the current state of apoptosis inducing therapy of melanoma.
Keyword Melanoma therapy
Drug resistance
Intrinsic apoptosis pathway
BH3-mimetic
SMAC-mimetic
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Accepted manuscript online: 29 MAR 2014

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
UQ Diamantina Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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Created: Fri, 30 May 2014, 22:06:50 EST by Nikolas Haass on behalf of UQ Diamantina Institute