Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen

Inglis, Julia J., Criado, Gabriel, Medghalchi, Mino, Andrews, Melanie, Sandison, Ann, Feldmann, Marc and Williams, Richard O. (2007) Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen. Arthritis Research and Therapy, 9 5: . doi:10.1186/ar2319


Author Inglis, Julia J.
Criado, Gabriel
Medghalchi, Mino
Andrews, Melanie
Sandison, Ann
Feldmann, Marc
Williams, Richard O.
Title Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen
Journal name Arthritis Research and Therapy   Check publisher's open access policy
ISSN 1478-6354
1478-6362
Publication date 2007-10-29
Year available 2007
Sub-type Article (original research)
DOI 10.1186/ar2319
Open Access Status DOI
Volume 9
Issue 5
Total pages 8
Place of publication London, United Kingdom
Publisher BioMed
Language eng
Formatted abstract
Many genetically modified mouse strains are now available on a C57BL/6 (H-2 b) background, a strain that is relatively resistant to collagen-induced arthritis. To facilitate the molecular understanding of autoimmune arthritis, we characterised the induction of arthritis in C57BL/6 mice and then validated the disease as a relevant pre-clinical model for rheumatoid arthritis.

C57BL/6 mice were immunised with type II collagen using different protocols, and arthritis incidence, severity, and response to commonly used anti-arthritic drugs were assessed and compared with DBA/1 mice. We confirmed that C57BL/6 mice are susceptible to arthritis induced by immunisation with chicken type II collagen and develop strong and sustained T-cell responses to type II collagen. Arthritis was milder in C57BL/6 mice than DBA/1 mice and more closely resembled rheumatoid arthritis in its response to therapeutic intervention. Our findings show that C57BL/6 mice are susceptible to collagen-induced arthritis, providing a valuable model for assessing the role of specific genes involved in the induction and/or maintenance of arthritis and for evaluating the efficacy of novel drugs, particularly those targeted at T cells.
Keyword Rheumatology
Rheumatology
RHEUMATOLOGY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article number R113.

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Thu, 29 May 2014, 22:57:59 EST by Melanie Shakespear on behalf of Institute for Molecular Bioscience