Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease

Affandi, Jacquita S, Hendry, Shona, Waterer, Grant, Thomson, Rachel, Wallace, Hilary, Burrows, Sally and Price, Patricia (2013) Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease. Human Immunology, 74 10: 1382-1385. doi:10.1016/j.humimm.2013.06.019


Author Affandi, Jacquita S
Hendry, Shona
Waterer, Grant
Thomson, Rachel
Wallace, Hilary
Burrows, Sally
Price, Patricia
Title Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease
Journal name Human Immunology   Check publisher's open access policy
ISSN 0198-8859
1879-1166
Publication date 2013-10-01
Sub-type Article (original research)
DOI 10.1016/j.humimm.2013.06.019
Volume 74
Issue 10
Start page 1382
End page 1385
Total pages 4
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Formatted abstract
The incidence of pulmonary non-tuberculous mycobacteria (NTM) disease in otherwise healthy adults is increasing as the population ages. The organisms are ubiquitous so susceptibility probably reflects a deficiency in a protective immune response. Here we investigate if singlenucleotide polymorphisms (SNP) affecting cytokines, chemokines and their receptors associate with pulmonary NTM disease. Samples from NTM patients (n = 79) and healthy controls (n = 188) were genotyped using TaqMan probes. Of the 16 SNPs assessed, IL28B-rs8099917*TG (rs8099917; P = 0.01, OR = 2.2), TNFA-1031*CC (rs1799964; p = 0.02, OR = 0.48) and IL10-1082*AA (rs1800896; P = 0.001, OR = 0.33) were significantly associated with NTM disease. IL28B-rs8099917 and IL10-1082 have been associated with perturbations of the Th1/Th2 balance, whilst TNFA-1031*CC associates with sensory neuropathy in HIV patients. IL10-1082 warrants further investigation because we observed high production of IL-10 in blood mononuclear cells from NTM patients.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 28 May 2014, 16:01:28 EST by Dr Rachel Thomson on behalf of Medicine - Greenslopes Private Hospital