Intermittent fasting attenuates increases in neurogenesis after ischemia and reperfusion and improves recovery

Manzanero, Silvia, Erion, Joanna R., Santro, Tomislay, Steyn, Frederik J., Chen, Chen, Arumugam, Thiruma V. and Stranahan, Alexis M. (2014) Intermittent fasting attenuates increases in neurogenesis after ischemia and reperfusion and improves recovery. Journal of Cerebral Blood Flow and Metabolism, 34 5: 897-905. doi:10.1038/jcbfm.2014.36


Author Manzanero, Silvia
Erion, Joanna R.
Santro, Tomislay
Steyn, Frederik J.
Chen, Chen
Arumugam, Thiruma V.
Stranahan, Alexis M.
Title Intermittent fasting attenuates increases in neurogenesis after ischemia and reperfusion and improves recovery
Journal name Journal of Cerebral Blood Flow and Metabolism   Check publisher's open access policy
ISSN 0271-678X
1559-7016
Publication date 2014-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.1038/jcbfm.2014.36
Open Access Status DOI
Volume 34
Issue 5
Start page 897
End page 905
Total pages 9
Place of publication New York, NY United States
Publisher Nature Publishing Group
Language eng
Abstract Intermittent fasting (IF) is neuroprotective across a range of insults, but the question of whether extending the interval between meals alters neurogenesis after ischemia remains unexplored. We therefore measured cell proliferation, cell death, and neurogenesis after transient middle cerebral artery occlusion (MCAO) or sham surgery (SHAM) in mice fed ad libitum (AL) or maintained on IF for 3 months. IF was associated with twofold reductions in circulating levels of the adipocyte cytokine leptin in intact mice, but also prevented further reductions in leptin after MCAO. IF/MCAO mice also exhibit infarct volumes that were less than half those of AL/MCAO mice. We observed a 30% increase in basal cell proliferation in the hippocampus and subventricular zone (SVZ) in IF/SHAM, relative to AL/SHAM mice. However, cell proliferation after MCAO was limited in IF mice, which showed twofold increases in cell proliferation relative to IF/SHAM, whereas AL/MCAO mice exhibit fivefold increases relative to AL/SHAM. Attenuation of stroke-induced neurogenesis was correlated with reductions in cell death, with AL/MCAO mice exhibiting twice the number of dying cells relative to IF/MCAO mice. These observations indicate that IF protects against neurological damage in ischemic stroke, with circulating leptin as one possible mediator.
Keyword Caloric restriction
Hippocampus
Intermittent fasting
Neurogenesis
Stroke
Subventricular zone
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID FT100100427
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Biomedical Sciences Publications
 
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