Efficacy and safety of fibrinogen concentrate in trauma patients-a systematic review

Aubron, C., Reade, M. C., Fraser, J. F. and Cooper, D. J. (2014) Efficacy and safety of fibrinogen concentrate in trauma patients-a systematic review. Journal of Critical Care, 29 3: e11-e17. doi:10.1016/j.jcrc.2013.12.011


Author Aubron, C.
Reade, M. C.
Fraser, J. F.
Cooper, D. J.
Title Efficacy and safety of fibrinogen concentrate in trauma patients-a systematic review
Journal name Journal of Critical Care   Check publisher's open access policy
ISSN 0883-9441
1557-8615
Publication date 2014-01-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.jcrc.2013.12.011
Open Access Status Not yet assessed
Volume 29
Issue 3
Start page e11
End page e17
Total pages 7
Place of publication Maryland Heights, MO United States
Publisher W.B. Saunders
Language eng
Abstract Purpose: Uncontrolled bleeding is the main preventable cause of death in severe trauma patients. Fibrinogen is the first coagulation factor to decrease during trauma-induced coagulopathy, suggesting that pharmacological replacement might assist early hemorrhage control. Several sources of fibrinogen are available; however, fibrinogen concentrate (FC) is not routinely used in trauma settings in most countries. The aim of this review is to summarize the available literature evaluating the use of FC in the management of severe trauma. Methods: Studies reporting the administration of FC in trauma patients published between January 2000 and April 2013 were identified from MEDLINE and from the Cochrane Library. Results: The systematic review identified 12 articles reporting FC usage in trauma patients: 4 case reports, 7 retrospective studies, and 1 prospective observational study. Three of these were not restricted to trauma patients. Conclusions: Despite methodological flaws, some of the available studies suggested that FC administration may be associated with a reduced blood product requirement. Randomized trials are warranted to determine whether FC improves outcomes in prehospital management of trauma patients or whether FC is superior to another source of fibrinogen in early hospital management of trauma patients.
Keyword Blood transfusion
Coagulopathy
Fibrinogen concentrate
Injuries
Outcome
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2015 Collection
 
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