Scale-free bursting in human cortex following hypoxia at birth

Roberts, James A., Iyer, Kartik K., Finnigan, Simon, Vanhatalo, Sampsa and Breakspear, Michael (2014) Scale-free bursting in human cortex following hypoxia at birth. Journal of Neuroscience, 34 19: 6557-6572. doi:10.1523/JNEUROSCI.4701-13.2014

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Author Roberts, James A.
Iyer, Kartik K.
Finnigan, Simon
Vanhatalo, Sampsa
Breakspear, Michael
Title Scale-free bursting in human cortex following hypoxia at birth
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 1529-2401
0270-6474
Publication date 2014-05-07
Year available 2014
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.4701-13.2014
Open Access Status File (Publisher version)
Volume 34
Issue 19
Start page 6557
End page 6572
Total pages 16
Place of publication Washington, DC, United States
Publisher Society for Neuroscience
Collection year 2015
Language eng
Abstract The human brain is fragile in the face of oxygen deprivation. Even a briefinterruption of metabolic supply at birth challenges an otherwise healthy neonatal cortex, leading to a cascade of homeostatic responses. During recovery from hypoxia, cortical activity exhibits a period of highly irregular electrical fluctuations known as burst suppression. Here we show that these bursts have fractal properties, with power-law scaling of burst sizes across a remarkable 5 orders of magnitude and a scale-free relationship between burst sizes and durations. Although burst waveforms vary greatly, their average shape converges to a simple form that is asymmetric at long time scales. Using a simple computational model, we argue that this asymmetry reflects activity-dependent changes in the excitatory-inhibitory balance of cortical neurons. Bursts become more symmetric following the resumption of normal activity, with a corresponding reorganization of burst scaling relationships. These findings place burst suppression in the broad class of scale-free physical processes termed crackling noise and suggest that the resumption of healthy activity reflects a fundamental reorganization in the relationship between neuronal activity and its underlying metabolic constraints.
Keyword Burst suppression
EEG
Hypoxia
Neonates
Neuronal avalanches
Scale-free
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2015 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 16 times in Scopus Article | Citations
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