Body mass index and dietary intervention: Implications for prognosis of amyotrophic lateral sclerosis

Ngo, S.T., Steyn, F.J. and McCombe, P.A. (2014) Body mass index and dietary intervention: Implications for prognosis of amyotrophic lateral sclerosis. Journal of the Neurological Sciences, 340 1-2: 5-12. doi:10.1016/j.jns.2014.02.035


Author Ngo, S.T.
Steyn, F.J.
McCombe, P.A.
Title Body mass index and dietary intervention: Implications for prognosis of amyotrophic lateral sclerosis
Journal name Journal of the Neurological Sciences   Check publisher's open access policy
ISSN 0022-510X
1878-5883
Publication date 2014-05-15
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.jns.2014.02.035
Open Access Status DOI
Volume 340
Issue 1-2
Start page 5
End page 12
Total pages 8
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Language eng
Subject 2728 Clinical Neurology
2808 Neurology
Abstract Amyotrophic lateral sclerosis (ALS) is an adult onset, neurodegenerative disease that is characterized by the loss of upper (corticospinal) and lower motor neurons. ALS is a multifactorial disease whereby a combination of genetic and environmental factors may contribute to disease pathogenesis. While the majority of studies indicate that the underlying causes for ALS pathology may be due to multiple defects at the cellular level, factors that have recently been identified to be associated with survival could lead to the development of beneficial interventions. In ALS, a higher pre-morbid body mass index (BMI) and the maintenance of BMI and nutritional state is associated with improved outcome. This review will focus on the associations between body composition and adiposity relative to disease duration and risk, and will discuss current evidence that supports the benefits of improving energy balance, and the maintenance of body mass through nutritional intervention in ALS.
Keyword Amyotrophic lateral sclerosis
Body mass index
Diet
Dietary intervention
Fat mass
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2015 Collection
School of Biomedical Sciences Publications
School of Medicine Publications
 
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