Experimental Trypanosoma evansi infection in the goat: II. Pathology

Dargantes, A. P., Campbell, R. S. F., Copeman, D. B. and Reid, S. A. (2005) Experimental Trypanosoma evansi infection in the goat: II. Pathology. Journal of Comparative Pathology, 133 4: 267-276. doi:10.1016/j.jcpa.2005.05.006

Author Dargantes, A. P.
Campbell, R. S. F.
Copeman, D. B.
Reid, S. A.
Title Experimental Trypanosoma evansi infection in the goat: II. Pathology
Formatted title
Experimental Trypanosoma evansi infection in the goat: II. Pathology
Journal name Journal of Comparative Pathology   Check publisher's open access policy
ISSN 0021-9975
Publication date 2005-11-01
Sub-type Article (original research)
DOI 10.1016/j.jcpa.2005.05.006
Volume 133
Issue 4
Start page 267
End page 276
Total pages 10
Place of publication Camden, London, United Kingdom
Publisher Elsevier
Language eng
Formatted abstract
Infection of male goats aged 8–10 months with 5000 or 50 000 organisms of a Mindanao strain of Trypanosoma evansi was observed over a period of 90 days. The infection induced clinical disease which was lethal, especially at the higher dose rate. Lesions were more acute in goats that received the higher dose. Gross and microscopical changes were not pathognomonic, except in the presence of demonstrable trypanosomes. At necropsy, a combination of lymphadenopathy, splenomegaly, hepatomegaly, testicular enlargement, anaemic signs and consolidation of the anterior lobes of the lungs was suggestive of surra. Testicular changes, especially aspermia, indicated probable infertility. The cytopathology of the lungs, liver, intestine, kidneys, testes, bone marrow, brain and other organs was immunological in nature, characterized by mononuclear infiltration of interstitial tissues, with minor cellular damage and the presence of trypanosomes. B- and T- cell responses were observed in the lymphatic system, but the findings indicated immunosuppression in the lymph nodes, spleen and bone marrow during the third month after infection. Exudative inflammatory changes were mild. It is suggested that the cytopathology of most haemophilic trypanosomal infections is predominantly an immunological process.
Keyword Goat
Parasitic infection
Trypanosoma evansi
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 17 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 27 May 2014, 01:55:27 EST by Simon Reid on behalf of School of Public Health