Physical exercise reduces the expression of RANTES and its CCR5 receptor in the adipose tissue of obese humans

Baturcam E., Abubaker J., Tiss A., Abu-Farha M., Khadir A., Al-Ghimlas F., Al-Khairi I., Cherian P., Elkum N., Hammad M., John J., Kavalakatt S., Lehe C., Warsame S., Behbehani K., Dermime S. and Dehbi M. (2014) Physical exercise reduces the expression of RANTES and its CCR5 receptor in the adipose tissue of obese humans. Mediators of Inflammation, 2014 1-13. doi:10.1155/2014/627150


Author Baturcam E.
Abubaker J.
Tiss A.
Abu-Farha M.
Khadir A.
Al-Ghimlas F.
Al-Khairi I.
Cherian P.
Elkum N.
Hammad M.
John J.
Kavalakatt S.
Lehe C.
Warsame S.
Behbehani K.
Dermime S.
Dehbi M.
Title Physical exercise reduces the expression of RANTES and its CCR5 receptor in the adipose tissue of obese humans
Journal name Mediators of Inflammation   Check publisher's open access policy
ISSN 1466-1861
0962-9351
Publication date 2014-01-01
Sub-type Article (original research)
DOI 10.1155/2014/627150
Open Access Status DOI
Volume 2014
Start page 1
End page 13
Total pages 13
Place of publication New York, NY, U.S.A.
Publisher Hindawi Publishing Corporation
Language eng
Subject 2403 Immunology
1307 Cell Biology
Abstract RANTES and its CCR5 receptor trigger inflammation and its progression to insulin resistance in obese. In the present study, we investigated for the first time the effect of physical exercise on the expression of RANTES and CCR5 in obese humans. Fifty-seven adult nondiabetic subjects (17 lean and 40 obese) were enrolled in a 3-month supervised physical exercise. RANTES and CCR5 expressions were measured in PBMCs and subcutaneous adipose tissue before and after exercise. Circulating plasma levels of RANTES were also investigated. There was a significant increase in RANTES and CCR5 expression in the subcutaneous adipose tissue of obese compared to lean. In PBMCs, however, while the levels of RANTES mRNA and protein were comparable between both groups, CCR5 mRNA was downregulated in obese subjects (P<0.05). Physical exercise significantly reduced the expression of both RANTES and CCR5 (P<0.05) in the adipose tissue of obese individuals with a concomitant decrease in the levels of the inflammatory markers TNF-IL-6, and P-JNK. Circulating RANTES correlated negatively with anti-inflammatory IL-1ra (P=0.001) and positively with proinflammatory IP-10 and TBARS levels (P<0.05). Therefore, physical exercise may provide an effective approach for combating the deleterious effects associated with obesity through RANTES signaling in the adipose tissue.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Queensland Children's Medical Research Institute Publications
 
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