Does tautomerization of FapyG influence its mutagenicity?

Jena, Nihar R., Mark, Alan E. and Mishra, Phool C. (2014) Does tautomerization of FapyG influence its mutagenicity?. ChemPhysChem, 15 9: 1779-1784. doi:10.1002/cphc.201400045

Author Jena, Nihar R.
Mark, Alan E.
Mishra, Phool C.
Title Does tautomerization of FapyG influence its mutagenicity?
Journal name ChemPhysChem   Check publisher's open access policy
ISSN 1439-4235
Publication date 2014-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.1002/cphc.201400045
Open Access Status
Volume 15
Issue 9
Start page 1779
End page 1784
Total pages 6
Place of publication Weinheim, Germany
Publisher Wiley - V C H Verlag
Language eng
Abstract Oxidative degradation of guanine to 2,6-diamino-4-oxo-5-for-mamidopyrimidine (FapyG) is believed to be mutagenic. It has been proposed recently that the enol tautomer of FapyG is mainly responsible for this effect leading to a guanine-to-thymine mutation (T. H. Gehrke, U. Lischke, K. L. Gasteiger, S. Schneider, S. Arnold, H. C. Muller, D. S. Stephenson, H. Zipse, T. Carell, Nat. Chem. Biol. 2013, 9, 455-461). Here, density functional methods suggest that the enol tautomer of FapyG might not be responsible for the proposed guanine-to-thymine mutation. Instead, it might result in a guanine-to-adenine mutation.
Keyword Chemistry, Physical
Physics, Atomic, Molecular & Chemical
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 22 May 2014, 20:04:52 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences