Absence of functional defect in CD8+ T cells during primary murine gammaherpesvirus-68 infection of I-Ab-/- mice

Belz, Gabrielle T., Liu, Haiyan, Andreansky, Samita, Doherty, Peter C. and Stevenson, Philip G. (2003) Absence of functional defect in CD8+ T cells during primary murine gammaherpesvirus-68 infection of I-Ab-/- mice. Journal of General Virology, 84 2: 337-341. doi:10.1099/vir.0.18821-0


Author Belz, Gabrielle T.
Liu, Haiyan
Andreansky, Samita
Doherty, Peter C.
Stevenson, Philip G.
Title Absence of functional defect in CD8+ T cells during primary murine gammaherpesvirus-68 infection of I-Ab-/- mice
Formatted title
Absence of functional defect in CD8+ T cells during primary murine gammaherpesvirus-68 infection of I-Ab-/- mice
Journal name Journal of General Virology   Check publisher's open access policy
ISSN 0022-1317
1465-2099
Publication date 2003-02-01
Year available 2003
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1099/vir.0.18821-0
Open Access Status Not yet assessed
Volume 84
Issue 2
Start page 337
End page 341
Total pages 5
Place of publication London, United Kingdom
Publisher The Microbiology Society
Language eng
Formatted abstract
The murine gammaherpesvirus-68 kills I-Ab-/- mice despite the presence of virus-specific CD8+ cytotoxic T lymphocytes (CTL). This has raised the possibility that these CTL are functionally abnormal. Here, no difference was observed between I-Ab-/- mice and I-Ab+/+ controls in virus-specific CTL function, T cell receptor usage, or surface phenotype. Thus CTL immunity was independent of CD4+ T cells in a chronic herpesvirus infection, but was still inadequate to control virus replication.
Keyword Biotechnology & Applied Microbiology
Virology
Biotechnology & Applied Microbiology
Virology
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
VIROLOGY
Q-Index Code CX
Q-Index Status Provisional Code
Grant ID G9800943
CA21765
AI29579
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collection: School of Chemistry and Molecular Biosciences
 
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