Antibody limits in vivo murid herpesvirus-4 replication by IgG Fc receptor-dependent functions

Wright, Debbie E., Colaco, Susanna, Colaco, Camilo and Stevenson, Philip G. (2009) Antibody limits in vivo murid herpesvirus-4 replication by IgG Fc receptor-dependent functions. Journal of General Virology, 90 11: 2592-2603. doi:10.1099/vir.0.014266-0


Author Wright, Debbie E.
Colaco, Susanna
Colaco, Camilo
Stevenson, Philip G.
Title Antibody limits in vivo murid herpesvirus-4 replication by IgG Fc receptor-dependent functions
Journal name Journal of General Virology   Check publisher's open access policy
ISSN 0022-1317
1465-2099
Publication date 2009-01-01
Year available 2009
Sub-type Article (original research)
DOI 10.1099/vir.0.014266-0
Volume 90
Issue 11
Start page 2592
End page 2603
Total pages 12
Place of publication Reading, Berks, United Kingdom
Publisher Society for General Microbiology
Language eng
Subject 2406 Virology
2700 Medicine
Abstract Antibody is an important antiviral defence. However, it is considered to do little against human gamma-herpesviruses, which establish predominantly latent infections regulated by T cells. One limitation on analysing these infections has been that latency is already well-established at clinical presentation; early infection may still be accessible to antibody. Here, using murid herpesvirus-4 (MuHV-4), we tested the impact of adoptively transferred antibody on early gamma-herpesvirus infection. Immune sera and neutralizing and non-neutralizing monoclonal antibodies (mAbs) all reduced acute lytic MuHV-4 replication. The reductions, even by neutralizing mAbs, were largely or completely dependent on host IgG Fc receptors. Therefore, passive antibody can blunt acute gamma-herpesvirus lytic infection, and does this principally by IgG Fc-dependent functions rather than by neutralization.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Clinical Medical Virology Centre Publications
 
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