A γ-herpesvirus immune evasion gene allow tumor cells in vivo to escape attack by cytotoxic T cells specific for a tumor epitope

Rice, Jason, de Lima, Brigitte, Stevenson, Freda K. and Stevenson, Philip G. (2002) A γ-herpesvirus immune evasion gene allow tumor cells in vivo to escape attack by cytotoxic T cells specific for a tumor epitope. European Journal of Immunology, 32 12: 3481-3487. doi:10.1002/1521-4141(200212)32:12<3481::AID-IMMU3481>3.0.CO;2-J


Author Rice, Jason
de Lima, Brigitte
Stevenson, Freda K.
Stevenson, Philip G.
Title A γ-herpesvirus immune evasion gene allow tumor cells in vivo to escape attack by cytotoxic T cells specific for a tumor epitope
Formatted title
A γ-herpesvirus immune evasion gene allow tumor cells in vivo to escape attack by cytotoxic T cells specific for a tumor epitope
Journal name European Journal of Immunology   Check publisher's open access policy
ISSN 0014-2980
1521-4141
Publication date 2002-12-01
Sub-type Article (original research)
DOI 10.1002/1521-4141(200212)32:12<3481::AID-IMMU3481>3.0.CO;2-J
Open Access Status Not yet assessed
Volume 32
Issue 12
Start page 3481
End page 3487
Total pages 7
Place of publication Weinheim, Germany
Publisher Wiley - V C H Verlag GmbH & Co. KGaA
Language eng
Formatted abstract
DNA vaccines induce CTL attack on target tumor epitopes, but tumor elimination in vivo also requires sufficient effector CTL to enter the site, guided by inflammatory chemokines. Many herpesviruses contain genes for chemokine and chemokine receptor-like proteins to protect infected cells from immune attack. To assess if this evasion strategy could protect tumor cells, we used a model where CTL specific for a single epitope were the only effectors. Following DNA vaccination, CTL eliminated tumor cells from a subcutaneous site. However, introducing a viral gene encoding a secreted broad-spectrum chemokine-binding protein (M3) into tumor cells completely blocked CTL attack. Transduced tumor cells also protected neighboring non-transduced tumor. These findings confirm the importance of chemokines for migration of CTL to a non-lymphoid site. They may have relevance for escape of human virus-associated malignancies, and raise the question of whether analogous molecules might contribute to the failure of CTL to eliminate tumors.
Keyword Chemokine
Chemotaxis
Tumor immunity
Vaccination
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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