Viral degradation of the MHC class I peptide loading complex

Boname, Jessica M., De Lima, Brigitte D., Lehner, Paul J. and Stevenson, Philip G. (2004) Viral degradation of the MHC class I peptide loading complex. Immunity, 20 3: 305-317. doi:10.1016/S1074-7613(04)00047-0

Author Boname, Jessica M.
De Lima, Brigitte D.
Lehner, Paul J.
Stevenson, Philip G.
Title Viral degradation of the MHC class I peptide loading complex
Journal name Immunity   Check publisher's open access policy
ISSN 1074-7613
Publication date 2004-03-01
Year available 2004
Sub-type Article (original research)
DOI 10.1016/S1074-7613(04)00047-0
Open Access Status Not yet assessed
Volume 20
Issue 3
Start page 305
End page 317
Total pages 13
Place of publication Cambridge, MA, United States
Publisher Cell Press
Language eng
Abstract The murine γ-herpesvirus-68 MK3 protein inhibits CD8+ T cell recognition by ubiquitinating the cytoplasmic tails of classical MHC class I heavy chains. Here we show that MK3 also provides the first example of a protein that degrades tapasin and TAP. The degradation was MK3 RING finger dependent and primarily affected TAP. MK3 associated with TAP1 in the absence of tapasin or TAP2, suggesting that TAP1 was a primary binding partner in the peptide loading complex. TAP2 also played a major role in MK3 stability and function. By degrading TAP, therefore, MK3 limited its own expression. However, TAP degradation also broadened the MK3 inhibitory repertoire and achieved a remarkable resistance to MHC class I upregulation by interferon-γ, suggesting that it represents a specific adaptation to immune evasion in lymphoid tissue.
Keyword Immunology
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID G9800943
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 86 times in Thomson Reuters Web of Science Article | Citations
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