Post-exposure vaccination improves gammaherpesvirus neutralization

Gillet, Laurent, May, Janet S. and Stevenson, Philip G. (2007) Post-exposure vaccination improves gammaherpesvirus neutralization. PLoS One, 2 9: e899-e899. doi:10.1371/journal.pone.0000899


Author Gillet, Laurent
May, Janet S.
Stevenson, Philip G.
Title Post-exposure vaccination improves gammaherpesvirus neutralization
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2007-09-19
Year available 2007
Sub-type Article (original research)
DOI 10.1371/journal.pone.0000899
Open Access Status DOI
Volume 2
Issue 9
Start page e899
End page e899
Total pages 8
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Language eng
Subject 1100 Agricultural and Biological Sciences
1300 Biochemistry, Genetics and Molecular Biology
2700 Medicine
Abstract Herpesvirus carriers transmit infection despite making virus-specific antibodies. Thus, their antibody responses are not necessarily optimal. An important question for infection control is whether vaccinating carriers might improve virus neutralization. The antibody response to murine gamma herpesvirus-68 (MHV-68) blocks cell binding, but fails to block and even enhances an IgG Fc receptor dependent infection of myeloid cell. Viral membrane fusion therefore remains infact. Although gH/gL-specific monoclonal antibodies can block infection at a post-binding step close to membrane fusion, gH/gL is a relatively minor antibody target in virus carriers. We show here that gH/gL-specific antibodies can block both Fc receptor-independent and Fc receptor-dependent infections, and that vaccinating virus carriers with a gH/gL fusion protein improves their capacity for virus neutralization both in vitro and in vivo. This approach has the potential to reduce herpesvirus transmission.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Clinical Medical Virology Centre Publications
 
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