Glycoprotein M is an essential lytic replication protein of the murine gammaherpesvirus 68

May, Janet S., Colaco, Susanna and Stevenson, Philip G. (2005) Glycoprotein M is an essential lytic replication protein of the murine gammaherpesvirus 68. Journal of Virology, 79 6: 3459-3467. doi:10.1128/JVI.79.6.3459-3467.2005

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Author May, Janet S.
Colaco, Susanna
Stevenson, Philip G.
Title Glycoprotein M is an essential lytic replication protein of the murine gammaherpesvirus 68
Journal name Journal of Virology   Check publisher's open access policy
ISSN 0022-538X
1098-5514
Publication date 2005-03-01
Sub-type Article (original research)
DOI 10.1128/JVI.79.6.3459-3467.2005
Open Access Status File (Publisher version)
Volume 79
Issue 6
Start page 3459
End page 3467
Total pages 9
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Subject 2403 Immunology
Abstract All herpesviruses encode a homolog of glycoprotein M (gM), which appears to function in virion morphogenesis. Despite its conservation, gM is inessential for the lytic replication of alphaherpesviruses. In order to address the importance of gM in gammaherpesviruses, we disrupted it in the murine gammaherpesvirus 68 (MHV-68). The mutant virus completely failed to propagate in normally permissive flbroblasts. The defective genome was rescued by either homologous recombination to restore the wild-type gM in situ or the insertion of an ectopic, intergenic expression cassette encoding gM into the viral genome. Thus, gM was essential for the lytic replication of MHV-68. Copyright
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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Citation counts: TR Web of Science Citation Count  Cited 38 times in Thomson Reuters Web of Science Article | Citations
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