Interference with dendritic cell populations limits early antigen presentation in chronic γ-herpesvirus-68 infection

Mount, Adele M., Masson, Frederick, Kupresanin, Fiona, Smith, Christopher M., May, Janet S., Van Rooijen, Nico, Stevenson, Philip G. and Belz, Gabrielle T. (2010) Interference with dendritic cell populations limits early antigen presentation in chronic γ-herpesvirus-68 infection. Journal of Immunology, 185 6: 3669-3676. doi:10.4049/jimmunol.1001079


Author Mount, Adele M.
Masson, Frederick
Kupresanin, Fiona
Smith, Christopher M.
May, Janet S.
Van Rooijen, Nico
Stevenson, Philip G.
Belz, Gabrielle T.
Title Interference with dendritic cell populations limits early antigen presentation in chronic γ-herpesvirus-68 infection
Journal name Journal of Immunology   Check publisher's open access policy
ISSN 0022-1767
1872-7905
Publication date 2010-09-15
Year available 2010
Sub-type Article (original research)
DOI 10.4049/jimmunol.1001079
Volume 185
Issue 6
Start page 3669
End page 3676
Total pages 8
Place of publication Amsterdam, The Netherlands
Publisher Elsevier BV
Language eng
Subject 2403 Immunology
Abstract A critical factor influencing the ability of the host to mount a robust immune response against a virus depends on the rapid recruitment of dendritic cells (DCs) presenting Ags. From the outset, this step sets the tempo for subsequent activation of virus-specific T cells. Despite this, how induction of the immune response might be modified by pathogens with the capacity to establish persistence is unclear. In this study, we have characterized the in vivo influence of murine γ-herpesvirus K3-mediated interference with MHC class I in DCs that drive the initial adaptive immune response. We observed that γ-herpesvirus could interfere with the very earliest phase of Ag presentation through K3 by directly targeting migratory and lymph node-resident DCs. These results show that a pathogen with the capacity to interfere with early Ag presentation can establish suboptimal conditions for rapid induction of the adaptive immune response and thus favor establishment of viral persistence. Copyright
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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