Important role for the murid herpesvirus 4 ribonucleotide reductase large subunit in host colonization via the respiratory tract

Gill, Michael B., May, Janet S., Colaco, Susanna and Stevenson, Philip G. (2010) Important role for the murid herpesvirus 4 ribonucleotide reductase large subunit in host colonization via the respiratory tract. Journal of Virology, 84 20: 10937-10942. doi:10.1128/JVI.00828-10


Author Gill, Michael B.
May, Janet S.
Colaco, Susanna
Stevenson, Philip G.
Title Important role for the murid herpesvirus 4 ribonucleotide reductase large subunit in host colonization via the respiratory tract
Journal name Journal of Virology   Check publisher's open access policy
ISSN 0022-538X
1098-5514
Publication date 2010-10-01
Year available 2010
Sub-type Article (original research)
DOI 10.1128/JVI.00828-10
Open Access Status DOI
Volume 84
Issue 20
Start page 10937
End page 10942
Total pages 6
Place of publication Washington, DC United States
Publisher American Society for Microbiology
Language eng
Subject 2403 Immunology
2406 Virology
Abstract Viral enzymes that process small molecules provide potential chemotherapeutic targets. A key constraint - the replicative potential of spontaneous enzyme mutants - has been hard to define with human gammaherpesviruses because of their narrow species tropisms. Here, we disrupted the murid herpesvirus 4 (MuHV-4) ORF61, which encodes its ribonucleotide reductase (RNR) large subunit. Mutant viruses showed delayed in vitro lytic replication, failed to establish infection via the upper respiratory tract, and replicated to only a very limited extent in the lower respiratory tract without reaching lymphoid tissue. RNR could therefore provide a good target for gammaherpesvirus chemotherapy. Copyright
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Clinical Medical Virology Centre Publications
 
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