Protection against wild-type murine gammaherpesvirus-68 latency by a latency-deficient mutant

Boname, Jessica M., Coleman, Heather M., May, Janet S. and Stevenson, Philip G. (2004) Protection against wild-type murine gammaherpesvirus-68 latency by a latency-deficient mutant. Journal of General Virology, 85 1: 131-135. doi:10.1099/vir.0.19592-0


Author Boname, Jessica M.
Coleman, Heather M.
May, Janet S.
Stevenson, Philip G.
Title Protection against wild-type murine gammaherpesvirus-68 latency by a latency-deficient mutant
Journal name Journal of General Virology   Check publisher's open access policy
ISSN 0022-1317
1465-2099
Publication date 2004-01-01
Year available 2004
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1099/vir.0.19592-0
Open Access Status Not yet assessed
Volume 85
Issue 1
Start page 131
End page 135
Total pages 5
Place of publication London, United Kingdom
Publisher The Microbiology Society
Language eng
Abstract A murine gammaherpesvirus-68 (MHV-68) mutant with deregulated transcription of its ORF50 transactivator was severely impaired in latency establishment. The deregulated virus showed reduced immunogenicity, probably reflecting a lower antigen load. However, it still elicited effective immunity to a subsequent wild-type (WT) virus challenge. Infection was not completely prevented, but was very substantially reduced in extent and the long-term level of WT viral DNA in lungs and spleens remained low. Thus latency-deficient MHV-68 illustrates a possible general approach to creating attenuated gammaherpesvirus vaccines that can protect against pathogenic WT infections.
Keyword Biotechnology & Applied Microbiology
Virology
Biotechnology & Applied Microbiology
Virology
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
VIROLOGY
Q-Index Code CX
Q-Index Status Provisional Code
Grant ID G9800943
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collection: School of Chemistry and Molecular Biosciences
 
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