The murine gammaherpesvirus-68 gp150 acts as an immunogenic decoy to limit virion neutralization

Gillet, Laurent, May, Janet S., Colaco, Susanna. and Stevenson, Philip G. (2007) The murine gammaherpesvirus-68 gp150 acts as an immunogenic decoy to limit virion neutralization. PLoS One, 2 8: e705-e705. doi:10.1371/journal.pone.0000705


Author Gillet, Laurent
May, Janet S.
Colaco, Susanna.
Stevenson, Philip G.
Title The murine gammaherpesvirus-68 gp150 acts as an immunogenic decoy to limit virion neutralization
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2007-08-08
Year available 2007
Sub-type Article (original research)
DOI 10.1371/journal.pone.0000705
Open Access Status DOI
Volume 2
Issue 8
Start page e705
End page e705
Total pages 10
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Language eng
Abstract Herpesviruses maintain long-term infectivity without marked antigenic variation. They must therefore evade neutralization by other means, Immune sera block murine gammaherpesvirus-68 (MHV-68) infection of fibroblasts, but fail to block and even enhance its infection of IgG Fc receptor-bearing cells, suggesting that the antibody response to infection is actually poor at ablating virion infectivity completely. Here we analyzed this effect further by quantitating the glycoprotein-specific antibody response of MHV-68 carrier mice. Gp150 was much the commonest glycoprotein target and played a predominant role in driving Fc receptor-dependent infection: when gp150-specific antibodies were boosted, Fc receptor-dependent infection increased; and when gp150-specific antibodies were removed, Fc receptor-dependent infection was largely lost. Neither gp150-specific monoclonal antibodies nor gp150-specific polyclonal sera gave significant virion neutralization. Gp150 therefore acts as an immunogenic decoy, distorting the MHV-68-specific antibody response to promote Fc receptor-dependent infection and so compromise virion neutralization. This immune evasion mechanism may be common to many non-essential herpesvirus glycoproteins.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Clinical Medical Virology Centre Publications
 
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