Immune mechanisms in murine gammaherpesvirus-68 infection

Stevenson, Philip G. and Efstathiou, Stacey (2005) Immune mechanisms in murine gammaherpesvirus-68 infection. Viral Immunology, 18 3: 445-456. doi:10.1089/vim.2005.18.445

Author Stevenson, Philip G.
Efstathiou, Stacey
Title Immune mechanisms in murine gammaherpesvirus-68 infection
Journal name Viral Immunology   Check publisher's open access policy
ISSN 0882-8245
Publication date 2005-10-07
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1089/vim.2005.18.445
Open Access Status Not yet assessed
Volume 18
Issue 3
Start page 445
End page 456
Total pages 12
Place of publication New Rochelle, NY, United States
Publisher Mary Ann Liebert
Language eng
Formatted abstract
The murine gamma-herpesvirus-68 (MHV-68) is a relative of the Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) that infects mice. All these gamma-herpesviruses are subject to immune control, but limit the impact of this control through immune evasion. Molecular evasion mechanisms have been described in abundance. However, we can only speculate what EBV and KSHV immune evasion contributes to the viral lifecycle. With MHV-68, we can analyze in vivo the contribution of immunological and virological gene expression to pathogenesis. While the physiology of infection seems quite well conserved between these viruses, the pathologies associated with immune suppression are obviously very different. MHV-68 is therefore more suited to uncovering the basic biology of gamma-herpesvirus infection than to testing disease interventions. Nevertheless, it may make some useful predictions about effective strategies of vaccination and infection control. This review aims to outline our current state of knowledge and to highlight some limitations of the MHV-68 model as it stands, in the hope of stimulating constructive progress.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 58 times in Thomson Reuters Web of Science Article | Citations
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