Immune evasion by gamma-herpesviruses

Stevenson, Philip G. (2004) Immune evasion by gamma-herpesviruses. Current Opinion in Immunology, 16 4: 456-462. doi:10.1016/j.coi.2004.05.002


Author Stevenson, Philip G.
Title Immune evasion by gamma-herpesviruses
Journal name Current Opinion in Immunology   Check publisher's open access policy
ISSN 0952-7915
1879-0372
Publication date 2004-08-01
Year available 2004
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.coi.2004.05.002
Open Access Status Not yet assessed
Volume 16
Issue 4
Start page 456
End page 462
Total pages 7
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Language eng
Abstract Persistent viruses, such as herpesviruses, transmit infection by evading cytotoxic T cells during lytic replication. The gamma-herpesviruses additionally evade T cells during the proliferation of latently infected lymphocytes to establish a persistent viral reservoir. Lytic gene expression in sites of lymphoproliferation appears to make a vital contribution to this latent immune evasion. Lytic antigens may therefore be a key immune target. Investigations into a murine gamma-herpesvirus have now provided evidence that vaccination with apathogenic, latency-deficient mutants can largely protect against subsequent wild-type gamma-herpesvirus latency establishment.
Keyword Cytotoxic T lymphocyte (CTL)
Endoplasmic reticulum (ER)
Epstein-Barr virus (EBV)
Interferon (IFN)
Interleukin (IL)
Kaposi's sarcoma-associated herpesvirus (KSHV)
Murine gamma-herpesvirus-68 (MHV-68)
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID G9800943
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Chemistry and Molecular Biosciences
 
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