Live imaging of endosome dynamics

Kerr, Markus and Teasdale, Rohan D. (2014) Live imaging of endosome dynamics. Seminars in Cell and Developmental Biology, 31 11-19. doi:10.1016/j.semcdb.2014.03.027


Author Kerr, Markus
Teasdale, Rohan D.
Title Live imaging of endosome dynamics
Journal name Seminars in Cell and Developmental Biology   Check publisher's open access policy
ISSN 1084-9521
1096-3634
Publication date 2014-04-01
Sub-type Article (original research)
DOI 10.1016/j.semcdb.2014.03.027
Volume 31
Start page 11
End page 19
Total pages 9
Place of publication London, United Kingdom
Publisher Academic Press
Language eng
Abstract When studying the living endosome one must first recognise that we are not studying a single discrete organelle but rather a highly dynamic interconnected network of membrane-bound compartments. Endocytosed molecules are sorted and transported through various polymorphic intracellular organelles that mature and interact with one another via fusion and fission events in a highly spatially and temporally co-ordinated manner. As such, we recognise that being a dynamic system, it must be studied in a dynamic fashion. Videomicroscopy has provided profound insights into the cell, and its use in the study of the living endosome has exemplified this supplying a unique perspective on this elusive organelle. In this review we will examine some of the seminal observations that this technology has contributed as well as survey the various assays, tools and technologies that can be applied to understanding the living endosome.
Keyword Endosome
Live-cell
Maturation
Microscopy
Probes
Trafficking
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Institute for Molecular Bioscience - Publications
 
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Created: Wed, 21 May 2014, 22:27:02 EST by Susan Allen on behalf of Institute for Molecular Bioscience