Downregulation of metallothionein-IIA expression occurs at immortalization

Duncan E.L. and Reddel R.R. (1999) Downregulation of metallothionein-IIA expression occurs at immortalization. Oncogene, 18 4: 897-903. doi:10.1038/sj.onc.1202370


Author Duncan E.L.
Reddel R.R.
Title Downregulation of metallothionein-IIA expression occurs at immortalization
Journal name Oncogene   Check publisher's open access policy
ISSN 0950-9232
Publication date 1999-01-28
Year available 1999
Sub-type Article (original research)
DOI 10.1038/sj.onc.1202370
Open Access Status Not yet assessed
Volume 18
Issue 4
Start page 897
End page 903
Total pages 7
Place of publication BASINGSTOKE
Publisher STOCKTON PRESS
Language eng
Subject 1312 Molecular Biology
1306 Cancer Research
1311 Genetics
Abstract Metallothioneins (MTs) may modulate a variety of cellular processes by regulating the activity of zinc-binding proteins, These proteins have been implicated in cell growth regulation, and their expression is abnormal in some tumors. In particular, MT-IIA is expressed 27-fold less in human colorectal tumors and tumor cell lines compared with normal tissue (Zhang et al,, 1997), Here we demonstrate that MT-IIA downregulation occurs when human cells become immortal, a key event in tumorigenesis, After immortalization MT-IIA expression remains inducible but the basal activity of the MT-IIA promoter is decreased, MT-IIA downregulation at immortalization is one of the most common immortalization-related changes identified to date, suggesting that MT-IIA has a role in this process.
Keyword Immortalization
Metallothionein-IIA
Senescence
SV40
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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