Pyrrhocoricin as a potential drug delivery vehicle for Cryptosporidium parvum

Boxell, Annika, Lee, Stephanie Hui Chin, Jefferies, Ryan, Watt, Paul, Hopkins, Richard, Reid, Simon, Armson, Anthony and Ryan, Una (2008) Pyrrhocoricin as a potential drug delivery vehicle for Cryptosporidium parvum. Experimental Parasitology, 119 2: 301-303. doi:10.1016/j.exppara.2008.02.005


Author Boxell, Annika
Lee, Stephanie Hui Chin
Jefferies, Ryan
Watt, Paul
Hopkins, Richard
Reid, Simon
Armson, Anthony
Ryan, Una
Title Pyrrhocoricin as a potential drug delivery vehicle for Cryptosporidium parvum
Journal name Experimental Parasitology   Check publisher's open access policy
ISSN 0014-4894
1090-2449
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.exppara.2008.02.005
Volume 119
Issue 2
Start page 301
End page 303
Total pages 3
Place of publication Maryland Heights, MO United States
Publisher Academic Press
Language eng
Subject 2403 Immunology
2405 Parasitology
2725 Infectious Diseases
Abstract This study analysed the intracellular delivery capacity of insect derived pyrrhocoricin with a peptide cargo in Cryptosporidium parvum in vitro using fluorescence microscopy. Results revealed that pyrrhocoricin was capable of acting as a delivery vehicle in transducing peptides across the parasite cell membrane for multiple life-cycle stages. The successful transduction may aid in target validation and the delivery of future peptide-based drugs against this important human pathogen.
Keyword Cryptosporidium
Delivery vehicle
Peptides
Pyrrhocoricin
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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