Contribution of FDOPA PET to radiotherapy planning for advanced glioma

Dowson, Nicholas, Fay, Michael, Thomas, Paul, Jeffree, Rosalind, McDowall, Robert, Winter, Craig, Coulthard, Alan, Smith, Jye, Gal, Yaniv, Bourgeat, Pierrick, Salvado, Olivier, Crozier S. and Rose, Stephen (2014). Contribution of FDOPA PET to radiotherapy planning for advanced glioma. In: Proceedings of the 17th International Conference on the Use of Computers in Radiation Therapy, ICCR 2013. 17th International Conference on the Use of Computers in Radiation Therapy (ICCR 2013), Melbourne, Australia, (). 6-9 May 2013. doi:10.1088/1742-6596/489/1/012028


Author Dowson, Nicholas
Fay, Michael
Thomas, Paul
Jeffree, Rosalind
McDowall, Robert
Winter, Craig
Coulthard, Alan
Smith, Jye
Gal, Yaniv
Bourgeat, Pierrick
Salvado, Olivier
Crozier S.
Rose, Stephen
Title of paper Contribution of FDOPA PET to radiotherapy planning for advanced glioma
Conference name 17th International Conference on the Use of Computers in Radiation Therapy (ICCR 2013)
Conference location Melbourne, Australia
Conference dates 6-9 May 2013
Proceedings title Proceedings of the 17th International Conference on the Use of Computers in Radiation Therapy, ICCR 2013   Check publisher's open access policy
Journal name Journal of Physics: Conference Series   Check publisher's open access policy
Place of Publication Bristol, United Kingdom
Publisher Institute of Physics Publishing
Publication Year 2014
Year available 2014
Sub-type Fully published paper
DOI 10.1088/1742-6596/489/1/012028
Open Access Status DOI
ISSN 1742-6588
1742-6596
Volume 489
Issue 1
Total pages 5
Language eng
Abstract/Summary Despite radical treatment with surgery, radiotherapy and chemotherapy, advanced gliomas recur within months. Geographic misses in radiotherapy planning may play a role in this seemingly ineluctable recurrence. Planning is typically performed on post-contrast MRIs, which are known to underreport tumour volume relative to FDOPA PET scans. FDOPA PET fused with contrast enhanced MRI has demonstrated greater sensitivity and specificity than MRI alone. One sign of potential misses would be differences between gross target volumes (GTVs) defined using MRI alone and when fused with PET. This work examined whether such a discrepancy may occur. Materials and Methods: For six patients, a 75 minute PET scan using 3,4-dihydroxy-6-18F-fluoro-L-phynel-alanine (18F-FDOPA) was taken within 2 days of gadolinium enhanced MRI scans. In addition to standard radiotherapy planning by an experienced radiotherapy oncologist, a second gross target volume (GTV) was defined by an experienced nuclear medicine specialist for fused PET and MRI, while blinded to the radiotherapy plans. The volumes from standard radiotherapy planning were compared to the PET defined GTV. Results: The comparison indicated radiotherapy planning would change in several cases if FDOPA PET data was available. PET-defined contours were external to 95% prescribed dose for several patients. However, due to the radiotherapy margins, the discrepancies were relatively small in size and all received a dose of 50 Gray or more. Conclusions: Given the limited size of the discrepancies it is uncertain that geographic misses played a major role in patient outcome. Even so, the existence of discrepancies indicates that FDOPA PET could assist in better defining margins when planning radiotherapy for advanced glioma, which could be important for highly conformal radiotherapy plans.
Subjects 3100 Physics and Astronomy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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