Normalizing metabolism in diabetic pregnancy: Is it time to target lipids?

Barrett, Helen L., Nitert, Marloes Dekker, McIntyre, H. David and Callaway, Leonie K. (2014) Normalizing metabolism in diabetic pregnancy: Is it time to target lipids?. Diabetes Care, 37 5: 1484-1493. doi:10.2337/dc13-1934


Author Barrett, Helen L.
Nitert, Marloes Dekker
McIntyre, H. David
Callaway, Leonie K.
Title Normalizing metabolism in diabetic pregnancy: Is it time to target lipids?
Journal name Diabetes Care   Check publisher's open access policy
ISSN 0149-5992
1935-5548
Publication date 2014-01-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2337/dc13-1934
Open Access Status DOI
Volume 37
Issue 5
Start page 1484
End page 1493
Total pages 10
Place of publication Alexandria, VA United States
Publisher American Diabetes Association Inc.
Language eng
Subject 2724 Internal Medicine
2712 Endocrinology, Diabetes and Metabolism
2902 Advanced and Specialised Nursing
Abstract Outcomes in pregnancies complicated by preexisting diabetes (type 1 and type 2) and gestational diabetes mellitus have improved, but there is still excess morbidity compared with normal pregnancy. Management strategies appropriately focus on maternal glycemia, which demonstrably improves pregnancy outcomes formother and infant. However, we may be reaching the boundaries of obtainable glycemic control for many women. It has been acknowledged that maternal lipids are important in pregnancies complicated by diabetes. Elevated maternal lipids are associated with preeclampsia, preterm delivery, and large-for-gestational-age infants. Despite this understanding, assessment of management strategies targeting maternal lipids has been neglected to date. Consideration needs to be given to whether normalizing maternal lipids would further improve pregnancy outcomes. This review examines the dyslipidemia associated with pregnancy complicated by diabetes, reviews possible therapies, and considers whether it is time to start actively managing this aspect of maternal metabolism.
Keyword Endocrinology & Metabolism
Endocrinology & Metabolism
ENDOCRINOLOGY & METABOLISM
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2015 Collection
School of Medicine Publications
 
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