A randomized trial of sodium-restriction on kidney function, fluid volume and adipokines in CKD patients

Campbell, Katrina L., Johnson, David W., Bauer, Judith, Hawley, Carmel M., Isbel, Nicole M., Stowasser, Michael, Whitehead, Jonathan P., Dimeski, Goce and McMahon, Emma (2014) A randomized trial of sodium-restriction on kidney function, fluid volume and adipokines in CKD patients. BMC Nephrology, 15 1: 57.1-57.6. doi:10.1186/1471-2369-15-57

Author Campbell, Katrina L.
Johnson, David W.
Bauer, Judith
Hawley, Carmel M.
Isbel, Nicole M.
Stowasser, Michael
Whitehead, Jonathan P.
Dimeski, Goce
McMahon, Emma
Title A randomized trial of sodium-restriction on kidney function, fluid volume and adipokines in CKD patients
Journal name BMC Nephrology   Check publisher's open access policy
ISSN 1471-2369
Publication date 2014-04-04
Year available 2014
Sub-type Article (original research)
DOI 10.1186/1471-2369-15-57
Open Access Status DOI
Volume 15
Issue 1
Start page 57.1
End page 57.6
Total pages 6
Place of publication London, United Kingdom
Publisher BioMed Central Ltd.
Language eng
Subject 2727 Nephrology
Abstract Background: Dietary sodium restriction is a key management strategy in chronic kidney disease (CKD). Recent evidence has demonstrated short-term reduction in blood pressure (BP) and proteinuria with sodium restriction, however the effect on other cardiovascular-related risk factors requires investigation in CKD. Methods. The LowSALT CKD study involved 20 hypertensive Stage III-IV CKD patients counselled by a dietitian to consume a low-sodium diet (<100 mmol/day). The study was a randomised crossover trial comparing 2 weeks of high-sodium (additional 120 mmol sodium tablets) and low-sodium intake (placebo). Measurements were taken after each crossover arm including BP (peripheral and central), adipokines (inflammation markers and adiponectin), volume markers (extracellular-to-intracellular [E/I] fluid ratio; N-terminal pro-brain natriuretic peptide [NT-proBNP]), kidney function (estimated Glomerular Filtration Rate [eGFR]) and proteinuria (urine protein-creatinine ratio [PCR] and albumin-creatinine ratio [ACR]). Outcomes were compared using paired t-test for each cross-over arm. Results: BP-lowering benefits of a low-sodium intake (peripheral BP (mean ± SD) 148/82 ± 21/12 mmHg) from high-sodium (159/87 ± 15/10 mmHg) intake were reflected in central BP and a reduction in eGFR, PCR, ACR, NTproBNP and E/I ratio. There was no change in inflammatory markers, total or high molecular weight adiponectin. Conclusions: Short-term benefits of sodium restriction on BP were reflected in significant change in kidney function and fluid volume parameters. Larger, long-term adequately powered trials in CKD are necessary to confirm these results. Trial registration. Universal Trial Number U1111-1125-2149 registered on 13/10/2011; Australian New Zealand Clinical Trials Registry Number ACTRN12611001097932 registered on 21/10/2011.
Keyword Blood pressure
Cardiovascular disease
Chronic kidney disease
Dietary sodium
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Human Movement and Nutrition Sciences Publications
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