Potential for layered double hydroxides-based, innovative drug delivery systems

Zhang, Kai, Xu, Zhi Ping, Lu, Ji, Tang, Zhi Yong, Zhao, Hui Jun, Good, David A. and Wei, Ming Qian (2014) Potential for layered double hydroxides-based, innovative drug delivery systems. International Journal of Molecular Sciences, 15 5: 7409-7428. doi:10.3390/ijms15057409

Author Zhang, Kai
Xu, Zhi Ping
Lu, Ji
Tang, Zhi Yong
Zhao, Hui Jun
Good, David A.
Wei, Ming Qian
Title Potential for layered double hydroxides-based, innovative drug delivery systems
Journal name International Journal of Molecular Sciences   Check publisher's open access policy
ISSN 1661-6596
Publication date 2014-04-29
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3390/ijms15057409
Open Access Status DOI
Volume 15
Issue 5
Start page 7409
End page 7428
Total pages 20
Place of publication Basel, Switzerland
Publisher Molecular Diversity Preservation International
Language eng
Subject 1606 Political Science
1605 Policy and Administration
1607 Social Work
1604 Human Geography
1503 Business and Management
1312 Molecular Biology
1706 Computer Science Applications
Abstract Layered Double Hydroxides (LDHs)-based drug delivery systems have, for many years, shown great promises for the delivery of chemical therapeutics and bioactive molecules to mammalian cells in vitro and in vivo. This system offers high efficiency and drug loading density, as well as excellent protection of loaded molecules from undesired degradation. Toxicological studies have also found LDHs to be biocompatible compared with other widely used nanoparticles, such as iron oxide, silica, and single-walled carbon nanotubes. A plethora of bio-molecules have been reported to either attach to the surface of or intercalate into LDH materials through co-precipitation or anion-exchange reaction, including amino acid and peptides, ATPs, vitamins, and even polysaccharides. Recently, LDHs have been used for gene delivery of small molecular nucleic acids, such as antisense, oligonucleotides, PCR fragments, siRNA molecules or sheared genomic DNA. These nano-medicines have been applied to target cells or organs in gene therapeutic approaches This review summarizes current progress of the development of LDHs nanoparticle drug carriers for nucleotides, anti-inflammatory, anti-cancer drugs and recent LDH application in medical research. Ground breaking studies will be highlighted and an outlook of the possible future progress proposed. It is hoped that the layered inorganic material will open up new frontier of research, leading to new nano-drugs in clinical applications.
Keyword Chemotherapy
Drug delivery
Gene therapy
Layered double hydroxides (LDHs)
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 28 times in Thomson Reuters Web of Science Article | Citations
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