Development and implementation of papillomavirus prophylactic vaccines

Frazer, Ian H. (2014) Development and implementation of papillomavirus prophylactic vaccines. Journal of Immunology, 192 9: 4007-4011. doi:10.4049/jimmunol.1490012


Author Frazer, Ian H.
Title Development and implementation of papillomavirus prophylactic vaccines
Journal name Journal of Immunology   Check publisher's open access policy
ISSN 1550-6606
0022-1767
Publication date 2014-05-01
Year available 2014
Sub-type Article (original research)
DOI 10.4049/jimmunol.1490012
Open Access Status DOI
Volume 192
Issue 9
Start page 4007
End page 4011
Total pages 5
Place of publication Bethesda, MD, United States
Publisher American Association of Immunologists
Language eng
Abstract Translation of basic scientific findings into practical patient outcomes is a significant exercise even when the goal is conceptually straightforward, as in the development of a vaccine for an infectious disease. Recognition of the association of cervical cancer with papillomavirus infection encouraged development of a vaccine to help with prevention of this very common cancer, causing over 250,000 deaths each year worldwide. To introduce a vaccine program, it was however necessary to develop a technology for making viral Ag, demonstrate that systemic immunization could provide mucosal surface protection in the genital tract, develop assays for vaccine potency, and understand enough about the epidemiology and natural history of the infection to plan effective intervention strategies. This process took ~25 years. The major hurdle, now that effective vaccines are available, is to ensure their deployment in the countries where they are most needed. The development and deployment of human papillomavirus vaccines demonstrate the benefits of collaborative research activity across the globe, and between academia and industry, to translate scientific discoveries into public health benefits.
Keyword Human papillomavirus
Papillomavirus
Virus-like particle
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
UQ Diamantina Institute Publications
 
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