Patched 1 and Patched 2 redundancy has a key role in regulating epidermal differentiation

Adolphe, Christelle, Nieuwenhuis, Erica, Villani, Rehan, Li, Zhu Juan, Kaur, Pritinder, Hui, Chi-chung and Wainwright, Brandon J. (2014) Patched 1 and Patched 2 redundancy has a key role in regulating epidermal differentiation. Journal of Investigative Dermatology, 134 7: 1981-1990. doi:10.1038/jid.2014.63


Author Adolphe, Christelle
Nieuwenhuis, Erica
Villani, Rehan
Li, Zhu Juan
Kaur, Pritinder
Hui, Chi-chung
Wainwright, Brandon J.
Title Patched 1 and Patched 2 redundancy has a key role in regulating epidermal differentiation
Journal name Journal of Investigative Dermatology   Check publisher's open access policy
ISSN 0022-202X
1523-1747
Publication date 2014-07-01
Year available 2014
Sub-type Article (original research)
DOI 10.1038/jid.2014.63
Volume 134
Issue 7
Start page 1981
End page 1990
Total pages 10
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
The Patched 1 (Ptch1) receptor has a pivotal role in inhibiting the activity of the Hedgehog (Hh) pathway and is therefore critical in preventing the onset of many human developmental disorders and tumor formation. However, the functional role of the mammalian Ptch2 paralogue remains elusive, particularly the extent to which it contributes to regulating the spatial and temporal activity of Hh signaling. Here we demonstrate in three independent mouse models of epidermal development that in vivo ablation of both Ptch receptors results in a more severe phenotype than loss of Ptch1 alone. Our studies indicate that concomitant loss of Ptch1 and Ptch2 activity inhibits epidermal lineage specification and differentiation. These results reveal that repression of Hh signaling through a dynamic Ptch regulatory network is a crucial event in lineage fate determination in the skin. In general, our findings implicate Ptch receptor redundancy as a key issue in elucidating the cellular origin of Hh-induced tumors. 
Keyword HF
Hair follicle
Hh
Hedgehog
IFE
Interfollicular epidermi
Ptch
Patched
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Diamantina Institute - Open Access Collection
Official 2015 Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 19 May 2014, 22:25:43 EST by Rehan Villani on behalf of UQ Diamantina Institute