Bacterial polyhydroxyalkanoate granules: biogenesis, structure, and potential use as nano-/micro-beads in biotechnological and biomedical applications

Grage, Katrin, Jahns, Anika C., Parlane, Natalie, Palanisamy, Rajasekaran, Rasiah, Indira A., Atwood, Jane A. and Rehm, Bernd H. A. (2009). Bacterial polyhydroxyalkanoate granules: biogenesis, structure, and potential use as nano-/micro-beads in biotechnological and biomedical applications. In: International Symposium on Biological Polyesters, Auckland, New Zealand, (660-669). 23-26 November 2008. doi:10.1021/bm801394s


Author Grage, Katrin
Jahns, Anika C.
Parlane, Natalie
Palanisamy, Rajasekaran
Rasiah, Indira A.
Atwood, Jane A.
Rehm, Bernd H. A.
Title of paper Bacterial polyhydroxyalkanoate granules: biogenesis, structure, and potential use as nano-/micro-beads in biotechnological and biomedical applications
Conference name International Symposium on Biological Polyesters
Conference location Auckland, New Zealand
Conference dates 23-26 November 2008
Journal name Biomacromolecules   Check publisher's open access policy
Place of Publication Washington, DC, United States
Publisher American Chemical Society
Publication Year 2009
Sub-type Fully published paper
DOI 10.1021/bm801394s
Open Access Status Not yet assessed
ISSN 1525-7797
1526-4602
Volume 10
Issue 4
Start page 660
End page 669
Total pages 10
Language eng
Abstract/Summary Polyhydroxyalkanoates (PHAs) are naturally occurring organic polyesters that are of interest for industrial and biomedical applications. These polymers are synthesized by most bacteria in times of unbalanced nutrient availability from a variety of substrates and they are deposited intracellularly as insoluble spherical inclusions or PHA granules. The granules consist of a polyester core, surrounded by a boundary layer with embedded or attached proteins that include the PHA synthase, phasins, depolymerizing enzymes, and regulatory proteins. Apart from ongoing industrial interest in the material PHA, more recently there has also been increasing interest in applications of the PHA granules as nano-/micro-beads after it was conceived that fusions to the granule associated proteins (GAPs) provide a way to immobilize target proteins at the granule surface. This review gives an overview of PHA granules in general, including biogenesis and GAPs, and focuses on their potential use as nano-/micro-beads in biotechnological and biomedical applications.
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Conference Paper
Sub-type: Fully published paper
Collection: UQ Diamantina Institute Publications
 
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Created: Mon, 19 May 2014, 21:28:43 EST by Jane Mullaney on behalf of UQ Diamantina Institute