Emotional regulation of pain: the role of noradrenaline in the amygdala

Strobel, Cornelia, Hunt, Sarah, Sullivan, Robert, Sun, Jian and Sah, Pankaj (2014) Emotional regulation of pain: the role of noradrenaline in the amygdala. Science China Life Sciences, 57 4: 384-390. doi:10.1007/s11427-014-4638-x


Author Strobel, Cornelia
Hunt, Sarah
Sullivan, Robert
Sun, Jian
Sah, Pankaj
Title Emotional regulation of pain: the role of noradrenaline in the amygdala
Journal name Science China Life Sciences   Check publisher's open access policy
ISSN 1674-7305
1869-1889
Publication date 2014-03-18
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s11427-014-4638-x
Open Access Status DOI
Volume 57
Issue 4
Start page 384
End page 390
Total pages 7
Place of publication Beijing, China
Publisher Zhongguo Kexue Zazhishe
Language eng
Subject 2300 Environmental Science
1300 Biochemistry, Genetics and Molecular Biology
1100 Agricultural and Biological Sciences
Abstract The perception of pain involves the activation of the spinal pathway as well as the supra-spinal pathway, which targets brain regions involved in affective and cognitive processes. Pain and emotions have the capacity to influence each other reciprocally; negative emotions, such as depression and anxiety, increase the risk for chronic pain, which may lead to anxiety and depression. The amygdala is a key-player in the expression of emotions, receives direct nociceptive information from the parabrachial nucleus, and is densely innervated by noradrenergic brain centers. In recent years, the amygdala has attracted increasing interest for its role in pain perception and modulation. In this review, we will give a short overview of structures involved in the pain pathway, zoom in to afferent and efferent connections to and from the amygdala, with emphasis on the direct parabrachio-amygdaloid pathway and discuss the evidence for amygdala's role in pain processing and modulation. In addition to the involvement of the amygdala in negative emotions during the perception of pain, this brain structure is also a target site for many neuromodulators to regulate the perception of pain. We will end this article with a short review on the effects of noradrenaline and its role in hypoalgesia and analgesia.
Keyword Learning
Pain
Parabrachial
Stress
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2015 Collection
 
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