The Yin and Yang of Wnt/Ryk axon guidance in development and regeneration

Clark, Charlotte E. J., Liu, Yaobo and Cooper, Helen M. (2014) The Yin and Yang of Wnt/Ryk axon guidance in development and regeneration. Science China Life Sciences, 57 4: 366-371. doi:10.1007/s11427-014-4640-3

Author Clark, Charlotte E. J.
Liu, Yaobo
Cooper, Helen M.
Title The Yin and Yang of Wnt/Ryk axon guidance in development and regeneration
Journal name Science China Life Sciences   Check publisher's open access policy
ISSN 1674-7305
Publication date 2014-04-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s11427-014-4640-3
Open Access Status DOI
Volume 57
Issue 4
Start page 366
End page 371
Total pages 6
Place of publication Beijing, China
Publisher Zhongguo Kexue Zazhishe / Science in China Press
Language eng
Subject 1300 Biochemistry, Genetics and Molecular Biology
2300 Environmental Science
1100 Agricultural and Biological Sciences
Abstract In the developing embryo, nascent axons navigate towards their specific targets to establish the intricate network of axonal connections linking neurons within the mature nervous system. Molecular navigational systems comprising repulsive and attractive guidance cues form chemotactic gradients along the pathway of the exploring growth cone. Axon-bound receptors detect these gradients and determine the trajectory of the migrating growth cone. In contrast to their benevolent role in the developing nervous system, repulsive guidance receptors are detrimental to the axon's ability to regenerate after injury in the adult. In this review we explore the essential and beneficial role played by the chemorepulsive Wnt receptor, Ryk/Derailed in axon navigation in the embryonic nervous system (the Yin function). Specifically, we focus on the role of Wnt5a/Rykmediated guidance in the establishment of two major axon tracts in the mammalian central nervous system, the corticospinal tract and the corpus callosum. Recent studies have also identified Ryk as a major suppressor of axonal regeneration after spinal cord injury. Thus, we also discuss this opposing aspect of Ryk function in axonal regeneration where its activity is a major impediment to axon regrowth (the Yang function).
Keyword Ryk
Wnt signalling
Axon guidance
Axonal regeneration
Spinal cord injury
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 30871425
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2015 Collection
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 6 times in Scopus Article | Citations
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