Relationships of chemical concentrations in maternal and cord blood: a review of available data

Aylward, L. L., Hays, S. M., Kirman, C. R., Marchitti, S. A., Kenneke, J. F., English, C., Mattison, D. R. and Becker, R. A. (2014) Relationships of chemical concentrations in maternal and cord blood: a review of available data. Journal of Toxicology and Environmental Health - Part B: Critical Reviews, 17 3: 175-203. doi:10.1080/10937404.2014.884956


Author Aylward, L. L.
Hays, S. M.
Kirman, C. R.
Marchitti, S. A.
Kenneke, J. F.
English, C.
Mattison, D. R.
Becker, R. A.
Title Relationships of chemical concentrations in maternal and cord blood: a review of available data
Journal name Journal of Toxicology and Environmental Health - Part B: Critical Reviews   Check publisher's open access policy
ISSN 1521-6950
1093-7404
Publication date 2014-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.1080/10937404.2014.884956
Volume 17
Issue 3
Start page 175
End page 203
Total pages 29
Place of publication Philadelphia, United States
Publisher Taylor and Francis
Language eng
Abstract The developing fetus is likely to be exposed to the same environmental chemicals as the mother during critical periods of growth and development. The degree of maternal-fetal transfer of chemical compounds will be affected by chemical and physical properties such as lipophilicity, protein binding, and active transport mechanisms that influence absorption and distribution in maternal tissues. However, these transfer processes are not fully understood for most environmental chemicals. This review summarizes reported data from more than 100 studies on the ratios of cord:maternal blood concentrations for a range of chemicals including brominated flame-retardant compounds, polychlorinated biphenyls (PCB), polychlorinated dibenzodioxins and dibenzofurans, organochlorine pesticides, perfluorinated compounds, polyaromatic hydrocarbons, metals, and tobacco smoke components. The studies for the chemical classes represented suggest that chemicals frequently detected in maternal blood will also be detectable in cord blood. For most chemical classes, cord blood concentrations were found to be similar to or lower than those in maternal blood, with reported cord:maternal ratios generally between 0.1 and 1. Exceptions were observed for selected brominated flame-retardant compounds, polyaromatic hydrocarbons, and some metals, for which reported ratios were consistently greater than 1. Careful interpretation of the data in a risk assessment context is required because measured concentrations of environmental chemicals in cord blood (and thus the fetus) do not necessarily imply adverse effects or risk. Guidelines and recommendations for future cord:maternal blood biomonitoring studies are discussed.
Keyword Fetus
Maternal–fetal transfer
Environmental chemicals
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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