Bulk endocytosis at neuronal synapses

Nguyen, Tam H., Qiu, XuFeng, Sun, Jian and Meunier, Frederic A. (2014) Bulk endocytosis at neuronal synapses. Science China Life Sciences, 57 4: 378-383. doi:10.1007/s11427-014-4636-z


Author Nguyen, Tam H.
Qiu, XuFeng
Sun, Jian
Meunier, Frederic A.
Title Bulk endocytosis at neuronal synapses
Journal name Science China Life Sciences   Check publisher's open access policy
ISSN 1674-7305
1869-1889
Publication date 2014-03-18
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s11427-014-4636-z
Open Access Status DOI
Volume 57
Issue 4
Start page 378
End page 383
Total pages 6
Place of publication Beijing, China
Publisher Science China Press
Language eng
Subject 2300 Environmental Science
1300 Biochemistry, Genetics and Molecular Biology
1100 Agricultural and Biological Sciences
Abstract Neurotransmitter-containing synaptic vesicle (SV) fusion with the nerve terminal plasma membrane initiates neurotransmission in response to neuronal excitation. Under mild stimulation, the fused vesicular membrane is retrieved via kiss-and-run and/or clathrin-mediated endocytosis, which is sufficient to maintain recycling of SVs. When neurons are challenged with very high stimulation, the number of fused SVs can be extremely high, resulting in significant plasma membrane addition. Under such conditions, a higher capacity retrieval pathway, bulk endocytosis, is activated to redress this large membrane imbalance. Despite first being described more than 40 years ago, the molecular mechanisms underpinning this important process have yet to be clearly defined. In this review, we highlight the current evidence for bulk endocytosis and its prevalence in various neuronal models, as well as discuss the underlying molecular components.
Keyword Bulk endocytosis
Neuron
Neurotransmission
Stimulation
Synapse
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2015 Collection
 
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