Total body glucose metabolism in the conscious, unrestrained piglet and its relation to body- and organ weight

Flecknell, P. A., Wootton, R. and John, Muriel (1980) Total body glucose metabolism in the conscious, unrestrained piglet and its relation to body- and organ weight. British Journal of Nutrition, 44 2: 193-203. doi:10.1079/BJN19800027

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Author Flecknell, P. A.
Wootton, R.
John, Muriel
Title Total body glucose metabolism in the conscious, unrestrained piglet and its relation to body- and organ weight
Journal name British Journal of Nutrition   Check publisher's open access policy
ISSN 0007-1145
1475-2662
Publication date 1980-09-01
Sub-type Article (original research)
DOI 10.1079/BJN19800027
Open Access Status File (Publisher version)
Volume 44
Issue 2
Start page 193
End page 203
Total pages 11
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Language eng
Formatted abstract
1. Neonatal hypoglycaemia is a relatively common clinical problem in children but ethical constraints limit the investigations that may be made in the newborn.

2. As a preliminary step to assess the suitability of the piglet as a model for glucose metabolism in man, whole-body glucose turnover and glucose pool size were measured using [2-3H]glucose in forty piglets from ten litters.

3. Glucose pool size was linearly related to brain weight. However, multiple regression showed that the most useful predictors of pool size were body-weight and resting plasma glucose concentration.

4. Glucose turnover was related to both brain weight and body-weight alone, but multiple regression showed that better predictors of turnover were liver weight, spleen weight and pancreas weight.

5. Similarities between our own results in piglets and those obtained in human neonates by Bier et al. (1977) extend not only to glucose turnover, but also to its relationship with body-and brain weight. These findings suggest that the piglet may be a useful model for the study of glucose metabolism in babies.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Online Health Publications
 
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