Homocysteine and carotid plaque stability: a cross-sectional study in Chinese adults

Yang, Xin, Zhou, Yong, Liu, Chao, Gao, Xiang, Wang, Anxin, Guo, Yuming, Li, Wen, Zhao, Xingquan and Liang, Wangnian (2014) Homocysteine and carotid plaque stability: a cross-sectional study in Chinese adults. PLoS One, 9 4: . doi:10.1371/journal.pone.0094935

Author Yang, Xin
Zhou, Yong
Liu, Chao
Gao, Xiang
Wang, Anxin
Guo, Yuming
Li, Wen
Zhao, Xingquan
Liang, Wangnian
Title Homocysteine and carotid plaque stability: a cross-sectional study in Chinese adults
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2014-04-15
Year available 2014
Sub-type Article (original research)
DOI 10.1371/journal.pone.0094935
Open Access Status DOI
Volume 9
Issue 4
Total pages 6
Place of publication San Francisco, United States
Publisher Public Library of Science
Language eng
Formatted abstract
Background and Purpose: This study aimed to explore the possible association of plasma total homocysteine with carotid plaque stability.
Methods: A cross-sectional study was conducted from 2010 to 2011. A stratified random sample of 2,919 Chinese participants aged 40 years or older was enrolled. Plasma total homocysteine levels were measured and carotid plaques were evaluated by ultrasonography. Logistic regression model was used to analyze the association of homocysteine levels to the progression of carotid plaque development, while adjusting for demographics and vascular risk factors.
Results: The mean level of plasma homocysteine in the subjects was 14.9 µmol/l. Along with increase in homocysteine level, the risk of advanced carotid plaque elevated (odds ratio = 1.28; 95% confidence interval = 1.09–1.51) after adjusting for age, sex, and other potential confounders. Stratified by sex, higher homocysteine level was strongly associated with advanced carotid plaque in men (OR = 1.41; 95% confidence interval = 1.17–1.70), but not in women.
Conclusion: The findings suggest that plasma level of homocysteine may be associated with advanced carotid plaque, which constitutes high risks of stroke, in male Chinese adults.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article #e94935

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 12 May 2014, 20:35:11 EST by Yuming Guo on behalf of School of Public Health